A-Mycin
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| a mycin 125 mg suspension | ৳ 84.75 | N/A |
Description
Overview of the medicine
A-Mycin 125 mg Suspension is an antibiotic used to treat a wide range of bacterial infections. It belongs to the macrolide class of antibiotics and works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Adult dosage varies by infection type and may require higher strength formulations; 125 mg suspension is typically for pediatric use. Consult a physician for specific adult dosing.
Elderly
No specific dosage adjustment required for elderly with normal renal and hepatic function.
Children
For children (6 months to 15 years): 10 mg/kg once daily for 3 days, or 10 mg/kg on day 1 followed by 5 mg/kg daily for 4 days. Max 500 mg/course.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment (CrCl > 10 mL/min). Use with caution in severe impairment.
How to Take
Oral administration. Can be taken with or without food. Shake the suspension well before use. Measure the dose accurately using the provided measuring device.
Mechanism of Action
Azithromycin binds to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting protein synthesis. This is generally considered bacteriostatic, but can be bactericidal in high concentrations against certain organisms.
Pharmacokinetics
Onset
Clinical effects typically observed within 1-2 hours.
Excretion
Mainly excreted unchanged in bile; a small portion via urine.
Half life
Terminal elimination half-life is 2-4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Digoxin
May increase serum digoxin concentrations; monitor digoxin levels.
Warfarin
Potentiate the effects of oral anticoagulants; monitor prothrombin time carefully.
Nelfinavir
May increase azithromycin serum concentrations.
Antacids containing aluminum or magnesium
Reduce peak serum levels of azithromycin; administer azithromycin at least 2 hours before or 4 hours after antacids.
Storage
Store dry powder below 30°C, protect from light and moisture. After reconstitution, store at room temperature (below 30°C) or in a refrigerator (2-8°C) as per product instructions, and discard after the specified period.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Azithromycin is excreted in breast milk; use with caution during lactation after assessing risks vs. benefits.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Digoxin
May increase serum digoxin concentrations; monitor digoxin levels.
Warfarin
Potentiate the effects of oral anticoagulants; monitor prothrombin time carefully.
Nelfinavir
May increase azithromycin serum concentrations.
Antacids containing aluminum or magnesium
Reduce peak serum levels of azithromycin; administer azithromycin at least 2 hours before or 4 hours after antacids.
Storage
Store dry powder below 30°C, protect from light and moisture. After reconstitution, store at room temperature (below 30°C) or in a refrigerator (2-8°C) as per product instructions, and discard after the specified period.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Azithromycin is excreted in breast milk; use with caution during lactation after assessing risks vs. benefits.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24 months for dry powder. Once reconstituted, typically 5-10 days when stored as directed by the manufacturer (e.g., at room temp or refrigerated).
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available (Patent expired)
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials for its efficacy and safety in various bacterial infections, including pediatric populations. Ongoing research explores new indications and formulations.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment)
- Renal function tests (in patients with severe renal impairment)
- INR/Prothrombin time (if co-administered with warfarin)
- ECG (in patients at risk of QT prolongation)
Doctor Notes
- Emphasize patient compliance to complete the full course to prevent resistance.
- Advise parents on correct measurement and administration of the suspension.
- Be aware of potential QT prolongation, especially in patients with pre-existing cardiac conditions or on other QT-prolonging drugs.
Patient Guidelines
- Complete the full course of antibiotics, even if symptoms improve.
- Do not save suspension for future use.
- Shake well before each use.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Azithromycin is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol consumption during treatment.
- Rest sufficiently.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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