Abazino
Generic Name
Abazin
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| abezino 150 mg tablet | ৳ 950.00 | ৳ 9,500.00 |
Description
Overview of the medicine
Abazino 150 mg Tablet contains Abazin, an Angiotensin II Receptor Blocker (ARB) used to treat high blood pressure (hypertension) and heart failure. It helps to relax blood vessels, lowering blood pressure and making it easier for your heart to pump blood.
Uses & Indications
Dosage
Adults
Hypertension: Initial dose 150 mg once daily, may be increased to 300 mg daily if needed. Heart Failure: Initial dose 75 mg once daily, titrated up to 150 mg or 300 mg daily as tolerated.
Elderly
No initial dosage adjustment is typically required, but monitoring of renal function is advised.
Renal_impairment
For severe renal impairment (CrCl <30 mL/min), initiate with a lower dose (e.g., 75 mg once daily) and monitor closely. Not recommended in patients undergoing dialysis.
How to Take
Abazino tablets should be swallowed whole with water, with or without food, once daily at approximately the same time each day.
Mechanism of Action
Abazin selectively blocks the binding of angiotensin II to the AT1 receptor, which is found in many tissues, including vascular smooth muscle and the adrenal gland. This blockade inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation, decreased blood pressure, and reduced sodium and water retention.
Pharmacokinetics
Onset
Antihypertensive effect begins within 2 hours, maximum effect within 2-4 hours.
Excretion
Excreted primarily via the feces (80%) and urine (20%) as unchanged drug.
Half life
Elimination half-life is approximately 6-9 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours. Bioavailability is approximately 30-40%.
Metabolism
Undergoes minimal hepatic metabolism, primarily through non-enzymatic cleavage.
Side Effects
Contraindications
- Hypersensitivity to Abazin or any excipients
- Pregnancy (second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR <60 mL/min/1.73 m²)
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Concomitant use is contraindicated in patients with diabetes or renal impairment due to increased risk of hyperkalemia, hypotension, and renal impairment.
NSAIDs (Non-Steroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal function deterioration, especially in elderly or dehydrated patients.
Potassium-sparing diuretics/Potassium supplements
May lead to hyperkalemia (e.g., spironolactone, amiloride).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited data are available on overdose in humans. The most likely manifestations of overdose would be hypotension and tachycardia; bradycardia could occur from parasympathetic stimulation. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Abazino is contraindicated during the second and third trimesters of pregnancy due to risks of fetal toxicity and death. It is not recommended during the first trimester. It is unknown whether Abazin is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Abazin or any excipients
- Pregnancy (second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR <60 mL/min/1.73 m²)
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Concomitant use is contraindicated in patients with diabetes or renal impairment due to increased risk of hyperkalemia, hypotension, and renal impairment.
NSAIDs (Non-Steroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal function deterioration, especially in elderly or dehydrated patients.
Potassium-sparing diuretics/Potassium supplements
May lead to hyperkalemia (e.g., spironolactone, amiloride).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited data are available on overdose in humans. The most likely manifestations of overdose would be hypotension and tachycardia; bradycardia could occur from parasympathetic stimulation. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Abazino is contraindicated during the second and third trimesters of pregnancy due to risks of fetal toxicity and death. It is not recommended during the first trimester. It is unknown whether Abazin is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Available in all pharmacies nationwide
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Patent pending
Clinical Trials
Extensive Phase III clinical trials demonstrated Abazino's efficacy in lowering blood pressure and reducing cardiovascular events in patients with hypertension and heart failure. Further post-marketing surveillance is ongoing.
Lab Monitoring
- Serum potassium levels (especially in patients with renal impairment or on potassium-sparing diuretics)
- Renal function (BUN and creatinine)
Doctor Notes
- Emphasize adherence to treatment, even when asymptomatic.
- Counsel patients on symptoms of hyperkalemia and hypotension.
- Advise caution with concomitant use of NSAIDs and potassium-sparing diuretics.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Abazino without consulting your doctor, even if you feel well.
- Report any unusual symptoms, especially swelling of the face, lips, or tongue, immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Abazino may cause dizziness or lightheadedness, especially when initiating therapy or increasing the dose. Patients should be advised to exercise caution when driving or operating machinery until they know how Abazino affects them.
Lifestyle Advice
- Maintain a healthy diet low in sodium.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.