acaluxen
Generic Name
Acaluxen 100 mg capsule
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| acaluxen 100 mg capsule | ৳ 1,000.00 | N/A |
Description
Overview of the medicine
Acaluxen 100 mg capsule is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
The usual adult dose is 100 mg orally, 2-3 times daily, preferably after meals. Do not exceed 300 mg per day.
Elderly
Lower doses may be required, and patients should be carefully monitored for adverse effects. Initial dose of 50 mg twice daily may be considered.
Renal_impairment
Use with caution. Dosage reduction may be necessary in patients with moderate to severe renal impairment. Avoid in severe renal failure.
How to Take
Take Acaluxen 100 mg capsule orally with a full glass of water, preferably after food or milk, to minimize gastrointestinal upset. Do not crush or chew the capsule.
Mechanism of Action
Acaluxen works by inhibiting cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever. By reducing prostaglandin production, acaluxen alleviates these symptoms.
Pharmacokinetics
Onset
Pain relief may begin within 30-60 minutes.
Excretion
Excreted mainly via the kidneys as metabolites and their conjugates; a small amount is excreted in feces.
Half life
Approximately 2-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations are reached within 1-2 hours after oral administration.
Metabolism
Primarily metabolized in the liver by oxidation and conjugation.
Side Effects
Contraindications
- Known hypersensitivity to acaluxen, aspirin, or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure, renal failure, or hepatic failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Methotrexate
May increase methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
ACE inhibitors and Diuretics
May reduce the hypotensive effect of these drugs and increase the risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is primarily supportive and symptomatic. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); Category D (third trimester). Avoid in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during lactation; consult a doctor before use.
Side Effects
Contraindications
- Known hypersensitivity to acaluxen, aspirin, or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure, renal failure, or hepatic failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Methotrexate
May increase methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
ACE inhibitors and Diuretics
May reduce the hypotensive effect of these drugs and increase the risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is primarily supportive and symptomatic. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); Category D (third trimester). Avoid in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during lactation; consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Pending
Clinical Trials
Acaluxen has undergone extensive Phase I, II, and III clinical trials demonstrating its efficacy and safety for indicated uses. Post-marketing surveillance is ongoing to monitor long-term effects.
Lab Monitoring
- Regular monitoring of renal function (serum creatinine, BUN) is recommended, especially in elderly patients or those with pre-existing renal impairment.
- Liver function tests (LFTs) should be checked periodically during long-term therapy.
- Complete blood count (CBC) to monitor for anemia, particularly with prolonged use.
Doctor Notes
- Counsel patients on the importance of taking acaluxen with food/milk to mitigate GI adverse effects.
- Monitor renal function, especially in elderly and high-risk patients.
- Be vigilant for signs of GI bleeding or cardiovascular events, particularly with prolonged use or higher doses.
Patient Guidelines
- Always take this medicine exactly as your doctor has told you.
- Do not exceed the recommended dose.
- Take with food or milk to reduce stomach upset.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Report any unusual stomach pain, black stools, or signs of bleeding immediately to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Acaluxen may cause dizziness, drowsiness, or visual disturbances in some patients. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid consuming alcohol while taking acaluxen, as it can increase the risk of gastrointestinal bleeding.
- Maintain adequate hydration, especially if you have renal impairment.
- Smoking can worsen gastrointestinal side effects; consider quitting.
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