Aceclof
Generic Name
Aceclofenac 100 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aceclof 100 mg tablet | ৳ 3.00 | N/A |
Description
Overview of the medicine
Aceclofenac 100 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It works by reducing the production of certain natural substances in the body that cause inflammation and pain.
Uses & Indications
Dosage
Adults
The recommended dose is 100 mg twice daily, one tablet in the morning and one in the evening.
Elderly
No dosage adjustment is generally required, but caution is advised, and the lowest effective dose should be used.
Renal_impairment
No evidence suggests the need for dose modification in patients with mild renal impairment. Caution is advised in moderate to severe renal impairment.
How to Take
Take orally, swallow the tablet whole with a glass of water, with or after food.
Mechanism of Action
Aceclofenac primarily acts as an inhibitor of prostaglandin synthesis. It selectively inhibits cyclooxygenase-2 (COX-2), the enzyme responsible for the synthesis of prostaglandins involved in inflammation, pain, and fever. It also exhibits some inhibition of COX-1, which is involved in maintaining gastric mucosal integrity.
Pharmacokinetics
Onset
Within 1-3 hours.
Excretion
Approximately two-thirds of the administered dose is excreted in the urine, mainly as hydroxylated metabolites, and one-third via the faeces.
Half life
Approximately 4 hours.
Absorption
Rapidly and completely absorbed orally, peak plasma concentrations reached in 1.25 to 3 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9, to 4'-hydroxyaceclofenac and other metabolites.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or any excipients
- Patients with active gastrointestinal bleeding or peptic ulcer
- History of NSAID-induced asthma, urticaria, or allergic-type reactions
- Severe heart failure, renal failure, or hepatic failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE Inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, stomach pain, dizziness, drowsiness, headache. Management involves gastric lavage, activated charcoal, and symptomatic and supportive treatment.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the third trimester due to potential risks to the fetus and complications during delivery. Avoid during lactation as aceclofenac may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or any excipients
- Patients with active gastrointestinal bleeding or peptic ulcer
- History of NSAID-induced asthma, urticaria, or allergic-type reactions
- Severe heart failure, renal failure, or hepatic failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE Inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, stomach pain, dizziness, drowsiness, headache. Management involves gastric lavage, activated charcoal, and symptomatic and supportive treatment.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the third trimester due to potential risks to the fetus and complications during delivery. Avoid during lactation as aceclofenac may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have established aceclofenac's efficacy and safety for various pain and inflammatory conditions. Bioequivalence studies confirm the interchangeability of generic formulations.
Lab Monitoring
- Renal function tests (creatinine, BUN)
- Liver function tests (ALT, AST)
- Complete blood count (CBC) for long-term therapy
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration.
- Assess cardiovascular and gastrointestinal risk factors before starting therapy and periodically thereafter.
- Avoid concomitant use with other NSAIDs or anticoagulants unless carefully monitored.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Take with food or after a meal to reduce stomach upset.
- Do not exceed the recommended dose.
- Report any unusual bleeding, black stools, or severe stomach pain to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption, as it may increase the risk of stomach problems.
- Maintain good hydration.
- Discuss any other medications or supplements with your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.