Acedone-Z Plus
Generic Name
Paracetamol and Zinc Sulfate
Manufacturer
Local Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| acedone z plus 400 mg suspension | ৳ 55.00 | N/A |
Description
Overview of the medicine
Acedone-Z Plus 400 mg Suspension is a combination medicine containing Paracetamol (Acetaminophen) for fever and pain relief, and Zinc Sulfate as a mineral supplement, often used as an adjunct in treating diarrhea and boosting immunity, especially in children.
Uses & Indications
Dosage
Adults
Adults: For fever and pain, generally 10-20 ml (400-800 mg Paracetamol) every 4-6 hours as needed. For zinc supplementation, typically 20 mg elemental zinc once daily for 10-14 days for diarrhea.
Elderly
Elderly: Same as adult dose, but caution should be exercised in patients with hepatic or renal impairment.
Renal_impairment
Renal Impairment: Dose adjustment may be necessary. Consult a physician for specific guidance.
How to Take
Administer orally. Shake the bottle well before each use. Use a measuring spoon or oral syringe for accurate dosing, especially for children.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system by inhibiting prostaglandin synthesis, thereby reducing fever and pain. Zinc is an essential trace element involved in numerous enzymatic functions, immune system regulation, and intestinal mucosal repair, contributing to improved immune response and reduced severity/duration of diarrhea.
Pharmacokinetics
Onset
Paracetamol: Analgesia and antipyresis typically begin within 30-60 minutes.
Excretion
Paracetamol and its metabolites are excreted mainly in the urine. Zinc is primarily excreted via feces, with minor urinary excretion.
Half life
Paracetamol: Approximately 2-3 hours. Zinc: Variable, depending on body stores and intake.
Absorption
Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Zinc absorption varies but is generally good.
Metabolism
Paracetamol is primarily metabolized in the liver, mainly by conjugation. Zinc is not metabolized but is incorporated into body proteins and enzymes.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol, Zinc, or any other component of the formulation
- Severe hepatic impairment or active liver disease
- Severe renal impairment (use with caution)
Drug Interactions
Alcohol
Chronic alcohol consumption increases the risk of liver toxicity with Paracetamol.
Warfarin
Paracetamol may enhance the anticoagulant effect of warfarin, increasing the risk of bleeding.
Iron supplements
Zinc and iron can compete for absorption; separate administration by at least 2 hours.
Tetracyclines & Quinolones
Zinc can chelate with these antibiotics, reducing their absorption. Administer at least 2 hours apart.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep tightly closed.
Overdose
Paracetamol overdose can cause severe, potentially fatal liver damage. Symptoms may include nausea, vomiting, abdominal pain, and loss of appetite, often appearing 24-48 hours after ingestion. Zinc overdose can cause nausea, vomiting, abdominal cramps, and diarrhea. Management involves gastric decontamination and supportive care. For Paracetamol overdose, acetylcysteine is the specific antidote.
Pregnancy & Lactation
Paracetamol is generally considered safe during pregnancy and lactation at recommended doses. Zinc is also essential during pregnancy and breastfeeding; however, consult a doctor before use, especially for higher doses.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol, Zinc, or any other component of the formulation
- Severe hepatic impairment or active liver disease
- Severe renal impairment (use with caution)
Drug Interactions
Alcohol
Chronic alcohol consumption increases the risk of liver toxicity with Paracetamol.
Warfarin
Paracetamol may enhance the anticoagulant effect of warfarin, increasing the risk of bleeding.
Iron supplements
Zinc and iron can compete for absorption; separate administration by at least 2 hours.
Tetracyclines & Quinolones
Zinc can chelate with these antibiotics, reducing their absorption. Administer at least 2 hours apart.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep tightly closed.
Overdose
Paracetamol overdose can cause severe, potentially fatal liver damage. Symptoms may include nausea, vomiting, abdominal pain, and loss of appetite, often appearing 24-48 hours after ingestion. Zinc overdose can cause nausea, vomiting, abdominal cramps, and diarrhea. Management involves gastric decontamination and supportive care. For Paracetamol overdose, acetylcysteine is the specific antidote.
Pregnancy & Lactation
Paracetamol is generally considered safe during pregnancy and lactation at recommended doses. Zinc is also essential during pregnancy and breastfeeding; however, consult a doctor before use, especially for higher doses.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture. Refer to the product packaging for specific expiry date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved in Bangladesh
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
The active ingredients, Paracetamol and Zinc, have been extensively studied individually and in combination for their indicated uses. Clinical evidence supports their efficacy and safety profile for fever, pain, and adjunctive treatment of diarrhea.
Lab Monitoring
- Liver function tests (especially in cases of overdose, prolonged high-dose therapy, or in patients with pre-existing liver conditions)
- Renal function tests (in patients with renal impairment)
- Serum zinc levels (if deficiency is suspected or for long-term high-dose supplementation)
Doctor Notes
- Advise parents/caregivers on proper dosing based on child's weight and age.
- Emphasize not to exceed the maximum daily dose of Paracetamol to prevent hepatotoxicity.
- Educate patients on potential drug interactions, especially with anticoagulants and certain antibiotics.
- In cases of diarrhea, emphasize the importance of oral rehydration therapy alongside zinc supplementation.
Patient Guidelines
- Always shake the bottle well before each use.
- Use the provided measuring device for accurate dosing.
- Do not exceed the recommended dose or frequency to avoid potential liver damage from Paracetamol.
- Consult a doctor if symptoms persist for more than a few days, or if new symptoms develop.
- Keep out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Acedone-Z Plus 400 mg Suspension is generally not expected to impair the ability to drive or operate machinery. However, if any side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain adequate hydration, especially during fever or diarrhea.
- Ensure a balanced diet to support overall health and immune function.
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