Acefenac
Generic Name
Aceclofenac
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| acefenac 100 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Acefenac 100 mg Tablet contains Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), used for pain relief and reduction of inflammation in various conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Uses & Indications
Dosage
Adults
The recommended dose is 100 mg twice daily, one tablet in the morning and one in the evening.
Elderly
No dosage adjustment is generally required, but caution should be exercised due to increased risk of side effects; the lowest effective dose should be used.
Renal_impairment
No dosage adjustment is usually necessary for mild renal impairment, but caution is advised. Avoid use in severe renal impairment.
How to Take
Acefenac 100 mg tablets should be swallowed whole with sufficient liquid, preferably with or after food, to minimize gastrointestinal discomfort.
Mechanism of Action
Aceclofenac works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever. By reducing prostaglandin production, Aceclofenac exerts its anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Pain relief usually starts within 1-2 hours.
Excretion
Approximately two-thirds of the administered dose is excreted in the urine and one-third in the feces.
Half life
Approximately 4-4.3 hours.
Absorption
Rapidly and completely absorbed after oral administration; peak plasma concentrations reached in 1.25 to 3 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9, into its main metabolite 4'-hydroxyaceclofenac.
Side Effects
Contraindications
- Hypersensitivity to Aceclofenac or any other NSAID
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure, hepatic or renal impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Lithium and Methotrexate
Increased plasma levels of lithium and methotrexate.
Cyclosporine and Tacrolimus
Increased risk of nephrotoxicity.
Diuretics and ACE inhibitors
Reduced efficacy and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, dizziness, headache, and drowsiness. In severe cases, renal failure and liver damage may occur. Management is primarily supportive and symptomatic; gastric lavage or activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Aceclofenac is contraindicated in the third trimester of pregnancy due to potential effects on fetal cardiovascular system. It should be avoided during early pregnancy and lactation unless the potential benefits outweigh the risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have established the efficacy and safety profile of Aceclofenac in various inflammatory and painful conditions, comparing it to other NSAIDs and placebos.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) periodically, especially in long-term use or in elderly patients.
- Liver function tests (e.g., AST, ALT) periodically.
- Complete Blood Count (CBC) to monitor for blood dyscrasias.
- Stool for occult blood, especially if GI symptoms arise.
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals.
- Monitor patients for signs and symptoms of GI bleeding and cardiovascular events, especially in high-risk populations.
- Assess renal and hepatic function periodically, particularly in elderly patients or those with pre-existing conditions.
Patient Guidelines
- Always take this medicine exactly as your doctor has told you.
- Do not exceed the recommended dose.
- Take with food or milk to reduce stomach upset.
- Inform your doctor about any other medications you are taking, especially blood thinners or other NSAIDs.
- Report any unusual symptoms, especially severe stomach pain or black/tarry stools, immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Acefenac may cause dizziness or drowsiness in some individuals. If you experience these side effects, you should avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking this medication as it may increase the risk of stomach irritation and bleeding.
- Maintain adequate hydration.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.