Acenac
Generic Name
Aceclofenac
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| acenac 100 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Acenac 100 mg Tablet contains Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) used for pain and inflammation. It provides relief from conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Uses & Indications
Dosage
Adults
The recommended dose is 100 mg twice daily, preferably with food.
Elderly
Lower doses may be considered, usually 100 mg once daily, with careful monitoring. Dose adjustment is generally not required unless renal or hepatic impairment is present.
Renal_impairment
Initiate with caution, usually 100 mg once daily. Avoid in severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
Swallow the tablet whole with water, preferably during or after a meal, to minimize gastrointestinal discomfort. Do not chew or crush the tablet.
Mechanism of Action
Aceclofenac primarily inhibits prostaglandin synthesis by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which reduces inflammation, pain, and fever. It also has some effects on COX-1.
Pharmacokinetics
Onset
Pain relief typically begins within 30 minutes to 1 hour.
Excretion
Approximately two-thirds of the administered dose is excreted in the urine and one-third in the faeces, mainly as hydroxylated metabolites.
Half life
The plasma elimination half-life is approximately 4 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract following oral administration, reaching peak plasma concentrations within 1.25 to 3 hours.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 2C9, to its main metabolite, 4'-hydroxyaceclofenac.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac, aspirin, or other NSAIDs
- Active gastrointestinal bleeding, ulceration, or perforation
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Severe renal impairment (creatinine clearance < 30 mL/min)
- Severe hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Reduced renal clearance of lithium, leading to increased plasma lithium levels and potential toxicity.
Methotrexate
Reduced renal tubular secretion of methotrexate, leading to increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment, especially in dehydrated patients.
Other NSAIDs or COX-2 inhibitors
Increased risk of adverse effects without significant additional benefit.
Warfarin and other anticoagulants
Increased risk of bleeding due to enhanced anticoagulant effect.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, and rarely, diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, and convulsions. In cases of significant poisoning, acute renal failure and liver damage are possible. Management is primarily supportive and symptomatic; gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Avoid during pregnancy, especially in the third trimester, due to potential fetal harm (e.g., premature closure of ductus arteriosus, renal dysfunction). Use with caution during lactation; small amounts may pass into breast milk, but adverse effects on the infant are unlikely with therapeutic doses.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac, aspirin, or other NSAIDs
- Active gastrointestinal bleeding, ulceration, or perforation
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Severe renal impairment (creatinine clearance < 30 mL/min)
- Severe hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Reduced renal clearance of lithium, leading to increased plasma lithium levels and potential toxicity.
Methotrexate
Reduced renal tubular secretion of methotrexate, leading to increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment, especially in dehydrated patients.
Other NSAIDs or COX-2 inhibitors
Increased risk of adverse effects without significant additional benefit.
Warfarin and other anticoagulants
Increased risk of bleeding due to enhanced anticoagulant effect.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, and rarely, diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, and convulsions. In cases of significant poisoning, acute renal failure and liver damage are possible. Management is primarily supportive and symptomatic; gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Avoid during pregnancy, especially in the third trimester, due to potential fetal harm (e.g., premature closure of ductus arteriosus, renal dysfunction). Use with caution during lactation; small amounts may pass into breast milk, but adverse effects on the infant are unlikely with therapeutic doses.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
Clinical Trials
Aceclofenac has undergone extensive clinical trials demonstrating its efficacy and tolerability in the management of various painful and inflammatory conditions. Studies often compare it with other NSAIDs, showing comparable efficacy with a potentially better gastrointestinal tolerability profile.
Lab Monitoring
- Liver function tests (LFTs) periodically, especially during long-term therapy
- Kidney function tests (serum creatinine, BUN) periodically
- Complete blood count (CBC) during prolonged therapy for signs of anemia or other hematologic effects
- Blood pressure monitoring
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Advise patients to report any signs of gastrointestinal bleeding, skin rash, or allergic reactions promptly.
- Monitor renal and hepatic function, and blood pressure during prolonged therapy.
- Exercise caution in patients with a history of cardiovascular disease, renal or hepatic impairment, or existing gastrointestinal issues.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Always take with food or immediately after meals to reduce stomach upset.
- Do not exceed the recommended dose or duration of treatment.
- Inform your doctor about any history of stomach ulcers, bleeding, or heart conditions.
- Report any unusual bleeding, black/tarry stools, or severe stomach pain immediately.
- Avoid concomitant use with other NSAIDs or aspirin unless advised by a doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Acenac may cause dizziness, drowsiness, or visual disturbances in some individuals. If you experience these effects, avoid driving, operating machinery, or performing tasks that require mental alertness.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Stay adequately hydrated by drinking plenty of fluids.
- Engage in regular, moderate exercise suitable for your condition.
- Avoid smoking, as it can increase the risk of gastrointestinal complications.
- Limit alcohol intake, as it may exacerbate gastrointestinal irritation.
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