Acenopan
Generic Name
Acenopan
Manufacturer
PharmaCorp Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| acenopan 100 mg tablet | ৳ 4.00 | N/A |
Description
Overview of the medicine
Acenopan 100 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) primarily used for the relief of pain, inflammation, and fever associated with various musculoskeletal and inflammatory conditions.
Uses & Indications
Dosage
Adults
Typically 100 mg once or twice daily, or as directed by a physician. Maximum daily dose usually 200 mg.
Elderly
Lower doses may be required; careful monitoring for adverse effects is recommended due to increased risk.
Renal_impairment
Caution advised; dose adjustment may be necessary based on creatinine clearance and individual response. Avoid in severe renal impairment.
How to Take
Take orally with a glass of water, preferably after meals or with food to minimize gastrointestinal upset.
Mechanism of Action
Acenopan exerts its therapeutic effects by inhibiting cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2. This inhibition leads to a reduction in the synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Onset of analgesic action typically occurs within 30-60 minutes.
Excretion
Mainly excreted in urine as metabolites, with a small portion excreted in feces.
Half life
Plasma elimination half-life is approximately 2-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes, forming inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to acenopan or other NSAIDs (e.g., aspirin, ibuprofen)
- Active peptic ulcer or gastrointestinal bleeding
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Severe renal or hepatic impairment
- Severe heart failure (NYHA Class III-IV)
- Third trimester of pregnancy
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Increased plasma lithium levels, potentially leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Other NSAIDs and Aspirin
Avoid concomitant use due to increased risk of adverse effects.
Diuretics and ACE inhibitors
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, dizziness, and headache. More severe cases may involve gastrointestinal bleeding, acute renal failure, or respiratory depression. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Acenopan is not recommended during the third trimester of pregnancy due to potential adverse effects on the fetus (e.g., premature closure of the ductus arteriosus). Use during the first and second trimesters only if clearly needed and the potential benefit outweighs the potential risk. Avoid during lactation as it may be excreted in breast milk and could potentially harm the nursing infant.
Side Effects
Contraindications
- Hypersensitivity to acenopan or other NSAIDs (e.g., aspirin, ibuprofen)
- Active peptic ulcer or gastrointestinal bleeding
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Severe renal or hepatic impairment
- Severe heart failure (NYHA Class III-IV)
- Third trimester of pregnancy
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Increased plasma lithium levels, potentially leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Other NSAIDs and Aspirin
Avoid concomitant use due to increased risk of adverse effects.
Diuretics and ACE inhibitors
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, dizziness, and headache. More severe cases may involve gastrointestinal bleeding, acute renal failure, or respiratory depression. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Acenopan is not recommended during the third trimester of pregnancy due to potential adverse effects on the fetus (e.g., premature closure of the ductus arteriosus). Use during the first and second trimesters only if clearly needed and the potential benefit outweighs the potential risk. Avoid during lactation as it may be excreted in breast milk and could potentially harm the nursing infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities
Patent Status
Generic
Clinical Trials
Phase III clinical trials demonstrated efficacy in reducing pain and inflammation in conditions like osteoarthritis and rheumatoid arthritis, with an acceptable safety profile compared to placebo. Post-marketing surveillance data continues to be collected.
Lab Monitoring
- Complete Blood Count (CBC) (especially for long-term use due to potential anemia or bleeding)
- Renal function tests (e.g., serum creatinine, BUN) (especially in elderly or renally impaired patients)
- Liver function tests (e.g., ALT, AST) (periodically for long-term use)
- Stool for occult blood (if gastrointestinal bleeding is suspected or for high-risk patients)
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration to minimize risks.
- Carefully assess patient's cardiovascular and gastrointestinal risk factors before initiating or continuing therapy.
- Monitor renal and hepatic function, and blood pressure, especially during long-term use or in high-risk patients.
- Advise patients on signs of serious adverse events and when to seek immediate medical attention.
Patient Guidelines
- Take Acenopan with food or milk to reduce stomach irritation.
- Do not exceed the prescribed dose or duration of treatment without consulting your doctor.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any signs of unusual bleeding, stomach pain, black stools, or severe rash immediately to your doctor.
- Avoid alcohol while taking this medicine as it can increase the risk of stomach problems.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Acenopan may cause dizziness or drowsiness in some individuals. Use caution when driving or operating machinery until you know how this medication affects you.
Lifestyle Advice
- Maintain a healthy diet and stay well-hydrated.
- Engage in regular, moderate exercise, if appropriate for your condition.
- Avoid smoking, as it can worsen gastrointestinal risks associated with NSAIDs.
- Consider stress management techniques for chronic pain.
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