Acep
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| acep 120 mg suspension | ৳ 35.00 | N/A |
Description
Overview of the medicine
Acep 120 mg Suspension is an oral preparation of Paracetamol (Acetaminophen) used for relieving pain and reducing fever, primarily in infants and children. It belongs to the class of analgesics and antipyretics.
Uses & Indications
Dosage
Adults
Not typically recommended for adults as a 120 mg/5 ml suspension due to low concentration; adult formulations are preferred.
Elderly
Not typically used in elderly; adult formulations are preferred, and caution is advised for liver/kidney issues.
Renal_impairment
Dose adjustment required in severe renal impairment (creatinine clearance <10 mL/min); dosage interval should be extended. Consult a physician.
How to Take
Administer orally using the provided measuring spoon or cup. Shake the bottle well before each use. Can be taken with or without food.
Mechanism of Action
Paracetamol works primarily by inhibiting prostaglandin synthesis in the central nervous system. It is thought to act preferentially on cyclooxygenase (COX) activity in the brain, reducing the production of prostaglandins responsible for pain and fever.
Pharmacokinetics
Onset
Onset of analgesic effect typically within 30-60 minutes; antipyretic effect within 30 minutes.
Excretion
Excreted mainly in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Plasma elimination half-life is approximately 1-4 hours, prolonged in liver dysfunction or in neonates.
Absorption
Rapid and complete absorption from the gastrointestinal tract after oral administration.
Metabolism
Primarily metabolized in the liver via conjugation with glucuronic acid and sulfate. A small amount is metabolized by cytochrome P450 to a highly reactive intermediate (NAPQI), which is detoxified by conjugation with glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Cholestyramine
Reduces paracetamol absorption if given within one hour of paracetamol.
Metoclopramide and Domperidone
May increase the rate of paracetamol absorption.
Warfarin and other oral anticoagulants
May enhance the anticoagulant effect, increasing bleeding risk, especially with prolonged daily use of paracetamol.
Carbamazepine, phenobarbital, phenytoin, rifampicin
May increase the risk of hepatotoxicity due to enzyme induction.
Storage
Store below 30°C in a dry place, protected from light and moisture. Do not freeze. Keep out of reach and sight of children.
Overdose
Overdose can cause severe, potentially fatal liver damage (hepatotoxicity). Symptoms may include nausea, vomiting, abdominal pain, and sweating, which may not appear until 24-48 hours after ingestion. Seek immediate medical attention. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation when used at recommended therapeutic doses. However, always consult a healthcare professional before use to weigh potential risks and benefits.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Cholestyramine
Reduces paracetamol absorption if given within one hour of paracetamol.
Metoclopramide and Domperidone
May increase the rate of paracetamol absorption.
Warfarin and other oral anticoagulants
May enhance the anticoagulant effect, increasing bleeding risk, especially with prolonged daily use of paracetamol.
Carbamazepine, phenobarbital, phenytoin, rifampicin
May increase the risk of hepatotoxicity due to enzyme induction.
Storage
Store below 30°C in a dry place, protected from light and moisture. Do not freeze. Keep out of reach and sight of children.
Overdose
Overdose can cause severe, potentially fatal liver damage (hepatotoxicity). Symptoms may include nausea, vomiting, abdominal pain, and sweating, which may not appear until 24-48 hours after ingestion. Seek immediate medical attention. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation when used at recommended therapeutic doses. However, always consult a healthcare professional before use to weigh potential risks and benefits.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date, when stored properly as per instructions.
Availability
Available in pharmacies, drug stores, and some supermarkets
Approval Status
Approved by major regulatory bodies worldwide
Patent Status
Generic, patents expired
WHO Essential Medicine
YesClinical Trials
Paracetamol has been extensively studied through numerous clinical trials over several decades, confirming its efficacy and safety profile for pain and fever management, particularly in pediatric populations. Ongoing research may explore specific applications or formulations.
Lab Monitoring
- Liver function tests (ALT, AST) in cases of suspected overdose or prolonged high-dose use.
- Serum paracetamol levels (in overdose management).
- Blood glucose (may be affected in severe overdose).
Doctor Notes
- Emphasize to parents the critical importance of accurate dose calculation based on the child's weight and age, using the provided measuring device.
- Stress the danger of exceeding the maximum daily dose and the risk of combining with other paracetamol-containing products.
- Educate on early signs of overdose (e.g., nausea, vomiting, abdominal pain) and the necessity for immediate medical attention.
- Advise on appropriate storage to prevent accidental ingestion by children.
Patient Guidelines
- Do not exceed the recommended dose for your child's age and weight.
- Do not use Acep 120 mg Suspension with other paracetamol-containing products to avoid overdose.
- Consult a doctor if fever persists for more than 3 days or pain for more than 5 days.
- Use the provided measuring device (spoon or cup) for accurate dosing; household spoons are not accurate.
- Store the medicine safely out of reach of children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to compensate for a missed one.
Driving Precautions
Paracetamol is not known to impair the ability to drive or operate machinery. However, if the child experiences any adverse effects that could affect alertness, caution should be exercised.
Lifestyle Advice
- Ensure adequate hydration, especially when fever is present, by offering plenty of fluids.
- Encourage sufficient rest to aid recovery from illness.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Acep Brand
Other medicines available under the same brand name
