Aceta
Generic Name
Paracetamol 120 mg suspension
Manufacturer
Example Manufacturer (e.g., Opsonin Pharma)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aceta 120 mg suspension | ৳ 35.00 | N/A |
Description
Overview of the medicine
Aceta 120 mg suspension contains Paracetamol, a widely used analgesic and antipyretic drug for the relief of mild to moderate pain and fever in children.
Uses & Indications
Dosage
Adults
Not typically used for adults in this specific concentration; adult formulations are usually 500 mg or 650 mg tablets. For children only.
Elderly
Not typically used for elderly in this specific concentration; adult formulations are usually 500 mg or 650 mg tablets. For children only.
Children
Based on age/weight, typically 10-15 mg/kg per dose, every 4-6 hours as needed. Do not exceed 5 doses in 24 hours. Refer to product leaflet for specific age/weight dosage recommendations.
Renal_impairment
In severe renal impairment, the dosing interval may need to be extended (e.g., every 6-8 hours instead of 4-6 hours). Consult a doctor.
How to Take
Oral administration. Shake the bottle well before each use. Use the measuring spoon or dropper provided for accurate dosing. Can be taken with or without food.
Mechanism of Action
Paracetamol primarily acts by inhibiting prostaglandin synthesis in the central nervous system. It has a weak anti-inflammatory effect due to its limited peripheral prostaglandin inhibition.
Pharmacokinetics
Onset
Pain relief within 15-30 minutes, fever reduction within 30-60 minutes.
Excretion
Excreted mainly in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1-4 hours (typically 2-3 hours in healthy adults).
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation, with a small portion oxidized by cytochrome P450 enzymes to a toxic intermediate (NAPQI) which is rapidly detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any other component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Cholestyramine
May decrease the absorption of paracetamol if taken within one hour.
Metoclopramide, Domperidone
May increase the absorption rate of paracetamol.
Warfarin and other oral anticoagulants
Increased anticoagulant effect and risk of bleeding with prolonged, regular daily use of paracetamol.
Carbamazepine, Phenobarbital, Phenytoin, Rifampicin
May increase the risk of paracetamol hepatotoxicity due to enzyme induction.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, pallor, and anorexia. Liver damage may occur 12-48 hours after ingestion. Management includes gastric lavage, activated charcoal, and intravenous N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation when taken at recommended doses for short periods. However, always consult a healthcare professional before use.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any other component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Cholestyramine
May decrease the absorption of paracetamol if taken within one hour.
Metoclopramide, Domperidone
May increase the absorption rate of paracetamol.
Warfarin and other oral anticoagulants
Increased anticoagulant effect and risk of bleeding with prolonged, regular daily use of paracetamol.
Carbamazepine, Phenobarbital, Phenytoin, Rifampicin
May increase the risk of paracetamol hepatotoxicity due to enzyme induction.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, pallor, and anorexia. Liver damage may occur 12-48 hours after ingestion. Management includes gastric lavage, activated charcoal, and intravenous N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation when taken at recommended doses for short periods. However, always consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, check expiry date on packaging.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Globally approved, Over-the-counter (OTC) in many regions
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Paracetamol is a well-established drug with extensive clinical data. Recent trials focus on specific populations or new formulations, not on the basic efficacy of 120 mg suspension.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in cases of suspected overdose or prolonged high-dose therapy.
- Renal function tests may be considered in patients with pre-existing renal impairment.
Doctor Notes
- Emphasize accurate dosing for pediatric patients using appropriate measuring devices.
- Advise parents about the risk of acetaminophen overdose and to avoid co-administration with other paracetamol-containing products.
- Counsel on signs of liver toxicity (e.g., jaundice, dark urine, abdominal pain) and when to seek immediate medical attention.
Patient Guidelines
- Always follow the dosage instructions on the label or as prescribed by a doctor.
- Do not exceed the recommended dose; overdose can cause severe liver damage.
- Avoid taking other medicines containing paracetamol simultaneously.
- If symptoms persist for more than 3 days, consult a doctor.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose.
Driving Precautions
Paracetamol does not typically affect the ability to drive or operate machinery. However, this suspension is primarily for children.
Lifestyle Advice
- Ensure adequate hydration, especially when experiencing fever.
- Rest is important for recovery from illness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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