Acflam 100 mg tablet should be swallowed whole with a sufficient quantity of liquid. It can be taken with or after food to minimize gastrointestinal discomfort.

Aceclofenac acts primarily as a selective COX-2 inhibitor, reducing the synthesis of prostaglandins, which are key mediators of inflammation, pain, and fever. It also has some inhibitory effect on COX-1.

• •Hypersensitivity to aceclofenac, aspirin, or other NSAIDs (e.g., patients who have experienced asthma, acute rhinitis, angioedema, or urticaria after taking aspirin or other NSAIDs)
• •Active or recurrent peptic ulcer/hemorrhage
• •Severe heart failure (NYHA Class II-IV)
• •Severe renal impairment
• •Severe hepatic impairment
• •Third trimester of pregnancy

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Symptoms of overdose may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, rarely diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, and convulsions. Management is symptomatic and supportive; gastric lavage, activated charcoal, and forced diuresis may be considered.

Pregnancy: Contraindicated in the third trimester due to risk of premature closure of the fetal ductus arteriosus. Use in the first and second trimesters only if the potential benefit outweighs the potential risk to the fetus, and at the lowest effective dose for the shortest duration. Lactation: Avoid during breastfeeding as aceclofenac is excreted in human milk.