Achil
Generic Name
achnil-200-mg-tablet
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| achnil 200 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Achil 200 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation associated with various conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It works by selectively inhibiting the COX-2 enzyme, which is involved in prostaglandin synthesis.
Uses & Indications
Dosage
Adults
Oral, 200 mg once daily, or 100 mg twice daily. Maximum daily dose 200 mg.
Elderly
No specific dose adjustment is usually required, but caution is advised due to increased risk of side effects. Consider lower starting dose.
Renal_impairment
Mild to moderate renal impairment: No dose adjustment. Severe renal impairment (CrCl < 30 mL/min): Not recommended.
How to Take
Take the tablet orally with water, preferably with food or after meals to minimize gastrointestinal discomfort. Do not crush, chew, or break the tablet.
Mechanism of Action
Achil selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins, inflammatory mediators. By reducing prostaglandin production, it diminishes inflammation, pain, and fever.
Pharmacokinetics
Onset
Pain relief typically begins within 30-60 minutes.
Excretion
Excreted mainly through urine (60%) and feces (40%) as metabolites.
Half life
Approximately 8-10 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 2-3 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (CYP2C9 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Achil or any NSAID (including aspirin)
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); Category D (third trimester). Avoid in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during lactation; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Achil or any NSAID (including aspirin)
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); Category D (third trimester). Avoid in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by Directorate General of Drug Administration (DGDA), Bangladesh
Patent Status
Patent active
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Achil 200 mg in the treatment of various inflammatory and painful conditions, comparing favorably to other NSAIDs with a potentially improved GI tolerability profile.
Lab Monitoring
- Complete Blood Count (CBC) - periodically for long-term therapy
- Liver Function Tests (LFTs) - periodically for long-term therapy
- Renal Function Tests (RFTs) - periodically, especially in elderly or patients with renal impairment
Doctor Notes
- Consider lowest effective dose for shortest duration to minimize risks.
- Monitor renal function, liver function, and blood pressure in patients on long-term therapy.
- Prescribe with caution in patients with a history of cardiovascular disease, hypertension, or gastrointestinal issues.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Take with food or milk to reduce stomach upset.
- Report any unusual bleeding, severe stomach pain, or allergic reactions to your doctor immediately.
- Avoid alcohol during treatment.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Achil may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Engage in regular, moderate exercise as advised by your healthcare provider.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.