Acidron

Administer by slow intravenous (IV) injection over at least 30 seconds, preferably 2-5 minutes, or by intramuscular (IM) injection. For IV infusion, dilute the contents of the ampoule and administer over 15 minutes.

Ondansetron is a selective serotonin 5-HT3 receptor antagonist. Serotonin 5-HT3 receptors are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the brain. By blocking these receptors, ondansetron prevents the initiation of the vomiting reflex.

• Hypersensitivity to Ondansetron or any component of the formulation.
• Concomitant use with apomorphine.

Store below 30°C. Protect from light. Do not freeze.

Symptoms of overdose include transient visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. Treatment is symptomatic and supportive. There is no specific antidote.

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Ondansetron is excreted in the milk of lactating rats; it is not known whether it is excreted in human milk. Exercise caution when administering to a nursing mother.

• Hypersensitivity to Ondansetron or any component of the formulation.
• Concomitant use with apomorphine.

Store below 30°C. Protect from light. Do not freeze.

Symptoms of overdose include transient visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. Treatment is symptomatic and supportive. There is no specific antidote.

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Ondansetron is excreted in the milk of lactating rats; it is not known whether it is excreted in human milk. Exercise caution when administering to a nursing mother.