Acliz
Generic Name
Acliz 50 mg Chewable Tablet
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| acliz 50 mg chewable tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Acliz 50 mg Chewable Tablet is an antihistamine used to relieve symptoms associated with seasonal and perennial allergic rhinitis, such as sneezing, runny nose, itchy nose or throat, and watery eyes. It is also effective in treating symptoms of chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
One 50 mg chewable tablet once daily, preferably in the evening. May be increased to 100 mg daily in divided doses if required.
Elderly
No specific dose adjustment is usually required unless there is significant renal or hepatic impairment. Start with the lowest effective dose.
Renal_impairment
For moderate to severe renal impairment (CrCl <50 mL/min), dose should be reduced to 25 mg once daily or 50 mg every other day.
How to Take
Chew the tablet thoroughly before swallowing. Can be taken with or without food. Do not swallow whole.
Mechanism of Action
Acliz selectively inhibits peripheral H1-receptors, thereby preventing histamine from binding to these receptors. This action blocks the effects of histamine, such as vasodilation, increased capillary permeability, and itching, which are responsible for allergic symptoms.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Excreted mainly through urine (both unchanged drug and metabolites) and feces.
Half life
Approximately 8-12 hours.
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations within 1-2 hours.
Metabolism
Primarily metabolized in the liver, likely via CYP450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Acliz or any of its components
- Children under 6 years of age (for chewable form)
Drug Interactions
Ketoconazole, Erythromycin
May increase plasma concentrations of Acliz due to inhibition of its metabolism.
CNS Depressants (e.g., alcohol, sedatives)
May enhance CNS depressant effects, leading to increased drowsiness.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, headache, and anticholinergic effects. Treatment is symptomatic and supportive. Gastric lavage or activated charcoal may be considered if recent ingestion. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. Excreted in breast milk; caution advised during lactation, as it may cause drowsiness in nursing infants.
Side Effects
Contraindications
- Hypersensitivity to Acliz or any of its components
- Children under 6 years of age (for chewable form)
Drug Interactions
Ketoconazole, Erythromycin
May increase plasma concentrations of Acliz due to inhibition of its metabolism.
CNS Depressants (e.g., alcohol, sedatives)
May enhance CNS depressant effects, leading to increased drowsiness.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, headache, and anticholinergic effects. Treatment is symptomatic and supportive. Gastric lavage or activated charcoal may be considered if recent ingestion. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. Excreted in breast milk; caution advised during lactation, as it may cause drowsiness in nursing infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Protected
Clinical Trials
Clinical trials demonstrated significant efficacy and safety in reducing symptoms of allergic rhinitis and urticaria compared to placebo, with a favorable tolerability profile.
Lab Monitoring
- No routine laboratory monitoring is required.
- Liver function tests may be considered in patients with pre-existing hepatic impairment.
Doctor Notes
- Advise patients about potential drowsiness and to avoid activities requiring mental alertness.
- Counsel on proper chewable tablet administration.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Avoid alcohol while taking this medicine.
- If drowsiness occurs, avoid driving or operating heavy machinery.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause drowsiness or dizziness. Patients should be advised to exercise caution when driving or operating machinery until they know how Acliz affects them.
Lifestyle Advice
- Identify and avoid allergens to minimize allergic reactions.
- Maintain good hydration.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.