Actifol
Generic Name
L-Methylfolate 15 mg
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| actifol 15 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
L-Methylfolate is the active form of folic acid, crucial for various bodily functions including cell division, red blood cell formation, and nervous system health. It bypasses metabolic defects, making it effective for individuals with MTHFR genetic variations.
Uses & Indications
Dosage
Adults
Typically 7.5 mg or 15 mg once daily, or as directed by a physician, depending on the indication.
Elderly
No specific dose adjustment generally required, but caution with comorbidities and other medications.
Renal_impairment
No specific dose adjustment required as L-Methylfolate is primarily excreted renally and generally considered safe in kidney impairment.
How to Take
Take orally with or without food, as directed by a healthcare professional. Swallow the tablet whole with water.
Mechanism of Action
L-Methylfolate is the primary biologically active form of folate. It functions as a methyl donor in various metabolic processes, including the conversion of homocysteine to methionine, synthesis of neurotransmitters (serotonin, dopamine, norepinephrine), and DNA synthesis. It is especially important for individuals with MTHFR gene polymorphisms who may have difficulty converting synthetic folic acid to its active form.
Pharmacokinetics
Onset
Within a few hours for plasma levels, though clinical effects may take days to weeks.
Excretion
Primarily renal, with some enterohepatic recirculation.
Half life
Approximately 3 hours for the parent compound, but total folate pool has a longer turnover.
Absorption
Rapidly absorbed from the intestine. Peak plasma concentrations reached within 1-3 hours.
Metabolism
Converted to other active folate forms; primarily through the folate cycle.
Side Effects
Contraindications
- Known hypersensitivity to L-Methylfolate or any component of the tablet.
- Untreated pernicious anemia (L-Methylfolate can mask vitamin B12 deficiency symptoms, potentially leading to neurological damage if B12 deficiency is not addressed).
Drug Interactions
Methotrexate
High doses of L-Methylfolate may theoretically reduce the efficacy of methotrexate, a folate antagonist.
Pyrimethamine
L-Methylfolate may reduce the efficacy of pyrimethamine, a folic acid antagonist.
Anticonvulsants (e.g., Phenytoin, Carbamazepine, Valproate)
May interact with folate metabolism; L-Methylfolate may potentially alter levels or efficacy of these drugs. Monitor patients carefully.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
L-Methylfolate is generally well-tolerated even at high doses with a low risk of toxicity. In case of suspected overdose, seek medical attention. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Generally considered safe and beneficial during pregnancy and lactation, especially for managing folate deficiency. Consult a healthcare provider before use.
Side Effects
Contraindications
- Known hypersensitivity to L-Methylfolate or any component of the tablet.
- Untreated pernicious anemia (L-Methylfolate can mask vitamin B12 deficiency symptoms, potentially leading to neurological damage if B12 deficiency is not addressed).
Drug Interactions
Methotrexate
High doses of L-Methylfolate may theoretically reduce the efficacy of methotrexate, a folate antagonist.
Pyrimethamine
L-Methylfolate may reduce the efficacy of pyrimethamine, a folic acid antagonist.
Anticonvulsants (e.g., Phenytoin, Carbamazepine, Valproate)
May interact with folate metabolism; L-Methylfolate may potentially alter levels or efficacy of these drugs. Monitor patients carefully.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
L-Methylfolate is generally well-tolerated even at high doses with a low risk of toxicity. In case of suspected overdose, seek medical attention. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Generally considered safe and beneficial during pregnancy and lactation, especially for managing folate deficiency. Consult a healthcare provider before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic, off-patent for active ingredient
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials and studies support the efficacy and safety of L-Methylfolate in conditions like folate deficiency, depression, and diabetic neuropathy, particularly in individuals with MTHFR gene polymorphisms. Ongoing research continues to explore its broader therapeutic applications.
Lab Monitoring
- Folate levels (plasma or red blood cell folate) may be monitored, especially initially and if symptoms persist.
- Homocysteine levels, particularly in cardiovascular risk patients.
- Vitamin B12 levels (important to rule out pernicious anemia before initiating high-dose L-Methylfolate therapy).
Doctor Notes
- Consider MTHFR gene testing for patients with chronic or refractory folate deficiency, or those with depression not responding to standard antidepressants, especially if homocysteine levels are elevated.
- Always check Vitamin B12 levels before initiating high-dose L-Methylfolate therapy to prevent masking symptoms of pernicious anemia.
- L-Methylfolate can be a valuable adjunctive therapy in certain neurological and psychiatric conditions where folate metabolism is compromised.
Patient Guidelines
- Take Actifol-15-mg-tablet exactly as prescribed by your doctor.
- Do not stop taking without consulting your doctor, even if you feel better.
- Inform your doctor about all other medications, vitamins, and herbal supplements you are currently taking.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, L-Methylfolate does not affect the ability to drive or operate machinery. If you experience any dizziness or unusual side effects, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet rich in natural folates (e.g., leafy green vegetables, legumes, fortified grains).
- Regular exercise and stress management may support overall health and mood.
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