Acubis
Generic Name
Losartan Potassium
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| acubis 25 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Acubis 25 mg Tablet contains Losartan Potassium, an Angiotensin II Receptor Blocker (ARB), used to treat high blood pressure (hypertension) and to reduce the risk of stroke in patients with high blood pressure and an enlarged heart. It is also used to treat kidney disease in patients with type 2 diabetes and a history of high blood pressure.
Uses & Indications
Dosage
Adults
Hypertension: Initial 50 mg once daily, adjusted based on blood pressure response. Max 100 mg once daily. Stroke risk reduction: Initial 50 mg once daily. Diabetic nephropathy: Initial 50 mg once daily, may be increased to 100 mg once daily.
Elderly
No initial dosage adjustment is typically required, but patients over 75 years may start with a lower dose (e.g., 25 mg once daily) under medical supervision.
Renal_impairment
No initial dosage adjustment is generally required for mild to moderate renal impairment. For severe renal impairment or dialysis patients, a lower starting dose (e.g., 25 mg once daily) may be considered.
How to Take
Acubis 25 mg Tablet can be taken with or without food, usually once daily. It should be swallowed whole with water.
Mechanism of Action
Losartan Potassium selectively blocks the binding of angiotensin II to the AT1 receptor, which is found in many tissues (e.g., vascular smooth muscle, adrenal gland). This blockade inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation, decreased aldosterone secretion, and reduced blood pressure.
Pharmacokinetics
Onset
Within 6 hours
Excretion
Approximately 35% excreted in urine and 60% in feces (as unchanged drug and metabolites).
Half life
Losartan: 2 hours; Active metabolite (E-3174): 6-9 hours
Absorption
Well absorbed from the gastrointestinal tract; undergoes significant first-pass metabolism. Bioavailability is about 33%.
Metabolism
Hepatic (CYP2C9 and CYP3A4) to an active carboxylic acid metabolite (E-3174), which is more potent than losartan.
Side Effects
Contraindications
- Hypersensitivity to losartan or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR <60 mL/min/1.73 m2)
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Diuretics and other antihypertensives
Additive hypotensive effects
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal dysfunction, especially in dehydrated or elderly patients.
Potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium
May lead to hyperkalemia
Storage
Store at room temperature (below 30°C), away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension and tachycardia; bradycardia could occur from parasympathetic stimulation. Treatment is symptomatic and supportive. If ingestion is recent, induce emesis or perform gastric lavage. Administer activated charcoal. Losartan and its active metabolite are not removed by hemodialysis.
Pregnancy & Lactation
Contraindicated in pregnancy, especially in the second and third trimesters, due to risk of fetal injury and death. Not recommended during breastfeeding as it is unknown if losartan is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to losartan or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR <60 mL/min/1.73 m2)
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Diuretics and other antihypertensives
Additive hypotensive effects
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal dysfunction, especially in dehydrated or elderly patients.
Potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium
May lead to hyperkalemia
Storage
Store at room temperature (below 30°C), away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension and tachycardia; bradycardia could occur from parasympathetic stimulation. Treatment is symptomatic and supportive. If ingestion is recent, induce emesis or perform gastric lavage. Administer activated charcoal. Losartan and its active metabolite are not removed by hemodialysis.
Pregnancy & Lactation
Contraindicated in pregnancy, especially in the second and third trimesters, due to risk of fetal injury and death. Not recommended during breastfeeding as it is unknown if losartan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
FDA Approved
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Losartan in hypertension, stroke risk reduction, and diabetic nephropathy.
Lab Monitoring
- Serum potassium levels (especially in patients with renal impairment or on potassium-sparing diuretics)
- Renal function (BUN, creatinine)
- Blood pressure monitoring
Doctor Notes
- Advise patients to monitor blood pressure regularly.
- Counsel on adherence to medication and lifestyle modifications.
- Caution against abrupt discontinuation without medical advice.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor, even if you feel well.
- Report any unusual side effects, especially swelling of the face, lips, or throat.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or fatigue. Patients should exercise caution when driving or operating machinery until they know how Acubis 25 mg Tablet affects them.
Lifestyle Advice
- Adopt a healthy diet low in sodium.
- Engage in regular physical activity.
- Avoid excessive alcohol consumption.
- Monitor blood pressure regularly at home.
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