Adults

1 capsule once or twice daily, or as directed by the physician. Treatment should continue until normal hemoglobin values are achieved and iron stores are replenished (typically 3-5 months).

Elderly

Similar to adult dosage, but caution should be exercised in patients with pre-existing medical conditions. Consult physician.

Renal_impairment

No specific dosage adjustment is usually required, but use with caution in severe renal impairment. Consult physician.

Onset

Clinical improvement in iron deficiency symptoms and hemoglobin levels typically begins within a few weeks of consistent therapy.

Excretion

Excretion of iron is minimal and occurs primarily via faeces (unabsorbed iron), urine, sweat, and shedding of mucosal cells.

Half life

Iron is not excreted rapidly, but rather conserved and reused in the body. It does not have a typical elimination half-life like other drugs; instead, it is stored in the body.

Absorption

Iron Polymaltose Complex is absorbed via an active regulatory mechanism, primarily in the duodenum and jejunum, leading to controlled absorption and lower risk of iron overload. Absorption is generally better than inorganic iron salts and less affected by food.

Metabolism

Absorbed iron is transported to the bone marrow for erythropoiesis, stored as ferritin or hemosiderin in reticuloendothelial cells, and incorporated into hemoglobin, myoglobin, and iron-containing enzymes.

Antacids

Antacids may reduce iron absorption, although the effect is less pronounced with Iron Polymaltose Complex. Separate administration by several hours.

Bisphosphonates

Iron may interfere with the absorption of bisphosphonates. Administer iron at a different time of day.

Tetracyclines & Quinolones

Iron may decrease the absorption of these antibiotics. Administer iron at least 2 hours before or 4 hours after these medications.