Adaben Duo
Generic Name
Adapalene + Benzoyl Peroxide
Manufacturer
Leading Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adaben duo 01 25 gel | ৳ 200.00 | N/A |
Description
Overview of the medicine
Adaben Duo 0.1-2.5 Gel is a topical medication used for the treatment of acne vulgaris. It combines Adapalene, a retinoid-like compound, and Benzoyl Peroxide, an antibacterial and keratolytic agent. This combination works to reduce inflammation, prevent clogged pores, and kill acne-causing bacteria.
Uses & Indications
Dosage
Adults
Apply a thin layer to affected areas once daily in the evening after washing.
Elderly
No specific dosage adjustments needed; use with caution for sensitive skin.
Renal_impairment
No specific dosage adjustments needed as systemic absorption is minimal.
How to Take
Topical use only. Wash skin gently with a mild cleanser and pat dry before application. Apply a thin film to all acne-affected areas, avoiding eyes, lips, and mucous membranes. Wash hands after application.
Mechanism of Action
Adapalene normalizes follicular keratinization and reduces inflammation, preventing microcomedone formation. Benzoyl Peroxide has bactericidal activity against Cutibacterium acnes (formerly P. acnes) and also possesses keratolytic properties, which helps to unblock pores.
Pharmacokinetics
Onset
Noticeable improvement typically within 1-4 weeks, full effect within 8-12 weeks.
Excretion
Primarily local degradation; any absorbed adapalene is excreted mainly via the biliary route; benzoic acid is excreted in urine.
Half life
Not clearly defined for topical application due to minimal systemic absorption; for systemic adapalene, it's several hours, but irrelevant for topical.
Absorption
Minimal systemic absorption through the skin; primarily local action.
Metabolism
Minimal systemic metabolism, primarily localized dermal metabolism for adapalene. Benzoyl peroxide is metabolized to benzoic acid.
Side Effects
Contraindications
- Hypersensitivity to adapalene, benzoyl peroxide, or any components of the gel.
- Broken, eczematous, or severely sunburnt skin.
Drug Interactions
Other topical acne preparations
Avoid concomitant use with other topical retinoids or medications with similar irritant effects as it may increase irritation.
Sulfur, resorcinol, salicylic acid
Use with caution and monitor for increased irritation if used concurrently.
Products with high alcohol content or strong astringents
Avoid use as they may cause excessive dryness or irritation.
Storage
Store below 25°C (77°F). Do not freeze. Keep out of reach of children. Protect from light.
Overdose
Topical overdose is unlikely to cause serious systemic effects due to minimal absorption. Excessive application may result in redness, peeling, or discomfort. Management includes symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category C (Adapalene). Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation; avoid application to the chest area to prevent infant exposure.
Side Effects
Contraindications
- Hypersensitivity to adapalene, benzoyl peroxide, or any components of the gel.
- Broken, eczematous, or severely sunburnt skin.
Drug Interactions
Other topical acne preparations
Avoid concomitant use with other topical retinoids or medications with similar irritant effects as it may increase irritation.
Sulfur, resorcinol, salicylic acid
Use with caution and monitor for increased irritation if used concurrently.
Products with high alcohol content or strong astringents
Avoid use as they may cause excessive dryness or irritation.
Storage
Store below 25°C (77°F). Do not freeze. Keep out of reach of children. Protect from light.
Overdose
Topical overdose is unlikely to cause serious systemic effects due to minimal absorption. Excessive application may result in redness, peeling, or discomfort. Management includes symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category C (Adapalene). Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation; avoid application to the chest area to prevent infant exposure.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, check specific packaging.
Availability
Pharmacies, drugstores, dermatologists' clinics
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of adapalene-benzoyl peroxide combination gel in treating acne vulgaris.
Lab Monitoring
- Generally not required for topical use unless systemic absorption is suspected in rare cases.
Doctor Notes
- Advise patients on proper application technique and emphasize consistency.
- Counsel patients about potential initial skin irritation and dryness, and how to manage it (e.g., using a moisturizer).
- Remind patients about sun protection measures.
Patient Guidelines
- Use only as directed by a healthcare professional.
- Avoid contact with eyes, lips, nostrils, and mucous membranes. If contact occurs, rinse thoroughly with warm water.
- Limit exposure to sunlight and artificial UV light (sunlamps). Use sunscreen and wear protective clothing.
- Skin irritation (redness, peeling, dryness, burning/stinging) may occur, especially during the initial weeks of treatment. This is usually mild and temporary.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember, unless it is almost time for the next dose. Do not double the dose to make up for a missed one. Continue with the regular schedule.
Driving Precautions
This medicine is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene and use non-comedogenic skincare products.
- Avoid picking or squeezing acne lesions to prevent scarring.
- Be patient; acne treatment takes time, and consistent use is key for best results.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.