Adagel Plus
Generic Name
Adapalene 0.1% / Benzoyl Peroxide 2.5%
Manufacturer
Glenmark Pharmaceuticals
Country
India
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adagel plus 01 25 gel | ৳ 200.00 | N/A |
Description
Overview of the medicine
Adagel Plus 0.1%/2.5% Gel is a combination topical medication used for the treatment of acne vulgaris. It combines Adapalene, a retinoid-like compound, with Benzoyl Peroxide, an antibacterial and keratolytic agent.
Uses & Indications
Dosage
Adults
Apply a thin layer of gel to all affected areas of the face and/or trunk once daily in the evening after washing. Avoid contact with eyes, lips, nostrils, and mucous membranes.
Elderly
No specific dose adjustment is required for elderly patients, as systemic absorption is minimal.
Renal_impairment
No specific dose adjustment is required for patients with renal impairment due to minimal systemic absorption.
How to Take
For topical dermatological use only. Cleanse the skin thoroughly before applying the gel. Apply a thin film to the entire affected area (not just individual lesions) once daily in the evening. Wash hands thoroughly after application.
Mechanism of Action
Adapalene normalizes follicular keratinization and has anti-inflammatory properties, which helps to prevent the formation of new acne lesions. Benzoyl Peroxide is an antimicrobial that reduces the number of Propionibacterium acnes (P. acnes) bacteria on the skin and also acts as a keratolytic agent, helping to shed dead skin cells and unclog pores.
Pharmacokinetics
Onset
Visible improvement typically observed within 1 to 4 weeks, with full therapeutic effect often seen after 8 to 12 weeks of continuous use.
Excretion
Systemically absorbed adapalene and its metabolites are excreted primarily via the biliary route. Benzoic acid, the metabolite of benzoyl peroxide, is excreted in the urine.
Half life
Systemic half-life is not clinically relevant for topical administration due to minimal absorption. Benzoyl peroxide is rapidly metabolized to benzoic acid in the skin.
Absorption
Both adapalene and benzoyl peroxide have minimal systemic absorption when applied topically, leading to very low plasma concentrations.
Metabolism
Systemically absorbed adapalene is primarily metabolized in the liver via O-demethylation, hydroxylation, and conjugation. Benzoyl peroxide is converted to benzoic acid within the skin.
Side Effects
Contraindications
- Hypersensitivity to adapalene, benzoyl peroxide, or any components of the gel.
- Pregnancy or planning to become pregnant.
Drug Interactions
Other topical retinoids or benzoyl peroxide products
Concurrent use may lead to increased irritation, redness, dryness, and peeling. Use with caution or avoid.
Products containing sulfur, resorcinol, or salicylic acid
May cause additive irritant effects; use with caution.
Storage
Store at room temperature (below 30°C). Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Excessive application of the gel will not produce faster or better results, but may lead to marked redness, peeling, or discomfort. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C (Adapalene is contraindicated in pregnancy by some guidelines). Avoid use during pregnancy and in women planning a pregnancy. During lactation, it is unknown whether adapalene or benzoyl peroxide are excreted in human milk. Use with caution, and apply to areas that will not come into contact with the infant.
Side Effects
Contraindications
- Hypersensitivity to adapalene, benzoyl peroxide, or any components of the gel.
- Pregnancy or planning to become pregnant.
Drug Interactions
Other topical retinoids or benzoyl peroxide products
Concurrent use may lead to increased irritation, redness, dryness, and peeling. Use with caution or avoid.
Products containing sulfur, resorcinol, or salicylic acid
May cause additive irritant effects; use with caution.
Storage
Store at room temperature (below 30°C). Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Excessive application of the gel will not produce faster or better results, but may lead to marked redness, peeling, or discomfort. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C (Adapalene is contraindicated in pregnancy by some guidelines). Avoid use during pregnancy and in women planning a pregnancy. During lactation, it is unknown whether adapalene or benzoyl peroxide are excreted in human milk. Use with caution, and apply to areas that will not come into contact with the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture. Refer to product packaging for specific expiry date.
Availability
Pharmacies, Drugstores
Approval Status
Approved (e.g., by regulatory bodies for topical acne treatment)
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of the combination of adapalene and benzoyl peroxide in the treatment of mild to moderately severe acne vulgaris.
Lab Monitoring
- No specific laboratory monitoring is generally required for topical use of this product.
Doctor Notes
- Advise patients on proper application technique and the importance of consistency.
- Counsel patients on potential initial irritation and how to manage it (e.g., start with alternate-day application if necessary).
- Emphasize daily use of broad-spectrum sunscreen due to increased photosensitivity.
Patient Guidelines
- Apply a thin layer to clean, dry skin.
- Avoid contact with eyes, lips, inside of the nose, and other mucous membranes.
- Use sunscreen and protective clothing when outdoors, as this product can increase sensitivity to sun.
- May bleach hair and colored fabrics (e.g., towels, clothing, bedding); avoid contact.
- Discontinue use and consult a doctor if severe irritation occurs.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered, unless it is almost time for the next dose. Do not apply a double dose to make up for a missed dose.
Driving Precautions
Adagel Plus 0.1%/2.5% Gel is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid picking or squeezing acne lesions.
- Use non-comedogenic cleansers and moisturizers.
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