Adali
Generic Name
Adalimumab
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adali 40 mg injection | ৳ 15,000.00 | N/A |
Description
Overview of the medicine
Adalimumab is a tumor necrosis factor (TNF) blocker used to treat various autoimmune diseases by reducing inflammation and immune responses.
Uses & Indications
Dosage
Adults
Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis: 40 mg every other week. Crohn's Disease, Ulcerative Colitis: Initial dose 160 mg (Day 1) followed by 80 mg (Day 15), then 40 mg every other week.
Elderly
No specific dose adjustment required based on age; however, monitor for increased incidence of infections.
Renal_impairment
No specific dose adjustment required for patients with renal impairment.
How to Take
Administer by subcutaneous injection into the thigh or abdomen. Patients can be trained to self-inject.
Mechanism of Action
Adalimumab binds specifically to TNF-alpha and blocks its interaction with cell surface TNF receptors, thereby inhibiting pro-inflammatory cytokine activity and downstream inflammatory processes.
Pharmacokinetics
Onset
Clinical response typically observed within weeks to months, depending on the indication.
Excretion
Elimination occurs through the reticuloendothelial system; no specific excretion pathway like small molecule drugs.
Half life
Approximately 10-20 days (average 14 days).
Absorption
Subcutaneous bioavailability is approximately 64%. Peak serum concentrations are reached in 5 days.
Metabolism
Adalimumab is a protein, metabolized by catabolic pathways similar to endogenous IgG. Not metabolized by cytochrome P450 enzymes.
Side Effects
Contraindications
- •Hypersensitivity to adalimumab or any excipient.
- •Active serious infections, including tuberculosis (TB), sepsis, and opportunistic infections.
- •Moderate to severe heart failure (NYHA Class III/IV).
Drug Interactions
Live vaccines
Avoid live vaccines during adalimumab treatment due to potential for infection.
Other biologic DMARDs (e.g., Anakinra, Abatacept)
Increased risk of serious infections when co-administered. Concomitant use is not recommended.
Storage
Store in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Keep out of the reach of children.
Overdose
No specific antidote for adalimumab overdose. Management should involve supportive care and treatment of symptoms.
Pregnancy & Lactation
Pregnancy: Use only if clearly needed after careful risk-benefit assessment. Lactation: Excreted into human milk at low levels. Consider developmental and health benefits of breastfeeding versus potential adverse effects on the breastfed child.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years; refer to the product packaging for exact expiry date.
Availability
Pharmacies, Hospitals
Approval Status
Approved (e.g., FDA, EMA, DGDA)
Patent Status
Biosimilar version available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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