Adapel
Generic Name
Adapalene 0.1% cream
Manufacturer
Example Pharmaceutical Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adapel 01 cream | ৳ 60.00 | N/A |
Description
Overview of the medicine
Adapalene 0.1% cream is a topical retinoid used for the treatment of acne vulgaris. It helps to clear existing acne lesions and prevent new ones from forming.
Uses & Indications
Dosage
Adults
Apply a thin layer of Adapel 0.1% cream to the affected areas of the face and/or trunk once daily in the evening after washing the skin.
Elderly
No specific dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with renal impairment due to minimal systemic absorption.
How to Take
For topical dermatological use only. Cleanse the affected area gently before application. Apply a thin film, avoiding contact with eyes, lips, nostrils, and mucous membranes. Wash hands after application.
Mechanism of Action
Adapalene modulates cellular differentiation, keratinization, and inflammatory processes. It binds to specific retinoic acid nuclear receptors, normalizing differentiation of follicular epithelial cells, which results in decreased microcomedone formation. It also has anti-inflammatory properties.
Pharmacokinetics
Onset
Therapeutic effects are typically observed after 8-12 weeks of treatment.
Excretion
Excretion is primarily via the biliary route.
Half life
Not significantly applicable due to minimal systemic absorption; systemic levels are often below quantification limits.
Absorption
Systemic absorption of adapalene from topical application is low (typically <0.25 ng/mL plasma levels).
Metabolism
Metabolized primarily by O-demethylation, hydroxylation, and conjugation.
Side Effects
Contraindications
- Hypersensitivity to adapalene or any components of the cream.
- Pregnancy (consult a doctor).
Drug Interactions
Other topical acne therapies
Use with caution. Products containing alpha hydroxy acids, glycolic acid, salicylic acid, sulfur, resorcinol, or benzoyl peroxide may cause cumulative irritating effects.
Medicated cleansers/cosmetics
Avoid concurrent use of abrasive soaps, cleansers, chemical peel solutions, strong astringents, or drying agents.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Excessive application of Adapel 0.1% cream will not produce more rapid or better results, and marked redness, peeling, or discomfort may occur. Oral ingestion of the topical cream may lead to vitamin A overdose symptoms; seek medical attention immediately.
Pregnancy & Lactation
Adapalene is contraindicated during pregnancy. Women of childbearing potential should use effective contraception. Use with caution during lactation; if used, avoid applying to the chest area to prevent accidental ingestion by the infant.
Side Effects
Contraindications
- Hypersensitivity to adapalene or any components of the cream.
- Pregnancy (consult a doctor).
Drug Interactions
Other topical acne therapies
Use with caution. Products containing alpha hydroxy acids, glycolic acid, salicylic acid, sulfur, resorcinol, or benzoyl peroxide may cause cumulative irritating effects.
Medicated cleansers/cosmetics
Avoid concurrent use of abrasive soaps, cleansers, chemical peel solutions, strong astringents, or drying agents.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Excessive application of Adapel 0.1% cream will not produce more rapid or better results, and marked redness, peeling, or discomfort may occur. Oral ingestion of the topical cream may lead to vitamin A overdose symptoms; seek medical attention immediately.
Pregnancy & Lactation
Adapalene is contraindicated during pregnancy. Women of childbearing potential should use effective contraception. Use with caution during lactation; if used, avoid applying to the chest area to prevent accidental ingestion by the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the manufacturing date.
Availability
Pharmacies nationwide
Approval Status
FDA Approved
Patent Status
Generic Available, Patent Expired
Clinical Trials
Adapalene has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of acne vulgaris. Studies have shown significant reductions in inflammatory and non-inflammatory lesions.
Lab Monitoring
- No routine laboratory monitoring is typically required for topical adapalene.
Doctor Notes
- Emphasize patient education on proper application technique and duration of treatment.
- Advise patients about potential initial worsening of acne and transient irritation.
- Stress the importance of daily sunscreen use.
- Monitor for signs of severe irritation or allergic reactions.
Patient Guidelines
- Use a mild cleanser and moisturizer regularly.
- Avoid excessive sun exposure and use broad-spectrum sunscreen with SPF 30 or higher.
- Avoid waxing on treated skin areas.
- Be patient, as therapeutic effects may take several weeks to become noticeable.
- Inform your doctor if irritation becomes severe or persistent.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered, unless it is almost time for the next dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Adapel 0.1% cream has no known effect on the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid picking or squeezing acne lesions.
- Use non-comedogenic cosmetics and skincare products.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.