Adebrox
Generic Name
Ambroxol Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adebrox 15 mg syrup | ৳ 40.00 | N/A |
Description
Overview of the medicine
Adebrox 15 mg syrup contains Ambroxol Hydrochloride, a mucolytic agent used to thin and loosen mucus in the airways, making it easier to cough up. It is used in conditions like acute and chronic bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.
Uses & Indications
Dosage
Adults
10 ml (30 mg) 2-3 times daily, or as directed by a physician.
Elderly
No specific dose adjustment is generally required, but caution is advised in those with severe renal or hepatic impairment.
Renal_impairment
Dosage reduction may be necessary in patients with severe renal impairment.
How to Take
Oral administration. May be taken with or without food. Use the provided measuring cup or spoon for accurate dosing.
Mechanism of Action
Ambroxol works by increasing serous mucus secretion and stimulating ciliary activity, thereby improving mucociliary clearance. It depolymerizes mucopolysaccharides directly, reducing the viscosity of bronchial secretions.
Pharmacokinetics
Onset
Secretolytic effect typically begins after 30 minutes.
Excretion
Mainly excreted renally (approximately 90%) as metabolites, with a small portion excreted unchanged in urine.
Half life
Approximately 7-12 hours.
Absorption
Rapidly and almost completely absorbed from the oral route. Peak plasma concentrations are reached after 1-2.5 hours.
Metabolism
Undergoes extensive first-pass metabolism in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Ambroxol or any component of the formulation.
- Rare hereditary conditions that may be incompatible with an excipient of the product.
Drug Interactions
Antibiotics (e.g., amoxicillin, cefuroxime, erythromycin, doxycycline)
Ambroxol may increase the penetration of some antibiotics into bronchial secretions, potentially enhancing their efficacy.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include gastrointestinal disturbances like nausea, vomiting, and diarrhea. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy, especially during the first trimester, only if clearly needed. Excreted into breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture. Refer to the product packaging for exact details.
Availability
Pharmacies and drugstores nationwide
Approval Status
Approved by DGDA
Patent Status
Generic (Patent expired)
Clinical Trials
Ambroxol has been widely studied in numerous clinical trials demonstrating its efficacy and safety in various respiratory conditions.
Lab Monitoring
- No routine laboratory monitoring is typically required.
Doctor Notes
- Advise patients about proper dosage and administration technique using the provided measuring device.
- Emphasize hydration to enhance mucolytic effect.
- Monitor for signs of hypersensitivity reactions, especially severe skin reactions, and discontinue if they occur.
Patient Guidelines
- Shake the bottle well before each use.
- Do not exceed the recommended dose.
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Consult a doctor if symptoms persist or worsen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Ambroxol is generally not expected to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness, avoid such activities.
Lifestyle Advice
- Stay well-hydrated by drinking plenty of fluids.
- Avoid smoking and exposure to irritants that can worsen respiratory conditions.
- Maintain good hygiene to prevent infections.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.