Medicine Information

Admox-DS

Name: Admox-DS
Brand: Admox-DS
Rating: 4.5 (117 reviews)

Capsule500 mgAntibacterial (Penicillin group)ATC: J01CA04

Generic Name

Amoxicillin

Manufacturer

Acme Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
admox ds 500 mg capsule	৳ 7.50	৳ 75.00

Description

Overview of the medicine

Admox-DS 500 mg Capsule contains Amoxicillin, a broad-spectrum penicillin antibiotic used to treat a wide range of bacterial infections.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia)

Urinary tract infections (e.g., cystitis, pyelonephritis)

Skin and soft tissue infections

Ear, nose, and throat infections (e.g., otitis media, sinusitis, tonsillitis)

Gonorrhoea (uncomplicated)

Helicobacter pylori eradication (in combination therapy)

Dosage

Adults

Usual dose is 250-500 mg every 8 hours, or 875 mg twice daily for severe infections. For Admox-DS 500 mg, typically 500 mg every 8 hours.

Elderly

No specific dose adjustment is required unless there is significant renal impairment. Monitor renal function.

Renal_impairment

For creatinine clearance 10-30 mL/min, 250-500 mg every 12 hours. For creatinine clearance less than 10 mL/min, 250-500 mg every 24 hours.

How to Take

Take the capsule orally with a glass of water, with or without food. It is recommended to complete the full course of treatment as prescribed by the doctor.

Mechanism of Action

Amoxicillin acts by inhibiting bacterial cell wall synthesis, leading to cell lysis and bacterial death. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall.

Pharmacokinetics

Onset

Within 30-60 minutes.

Excretion

Primarily excreted unchanged by the kidneys via tubular secretion and glomerular filtration. Approximately 60-70% of an oral dose is excreted in the urine within 6 hours.

Half life

Approximately 1-1.5 hours in adults with normal renal function.

Absorption

Rapidly and well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1-2 hours after oral administration.

Metabolism

Limited metabolism, mainly excreted unchanged.

Side Effects

Contraindications

Hypersensitivity to amoxicillin, any other penicillin, or to any of the excipients.
History of severe immediate hypersensitivity reaction (e.g., anaphylaxis) to another beta-lactam agent (e.g., cephalosporin, carbapenem or monobactam).

Drug Interactions

Allopurinol

Increased incidence of skin rash, especially in patients with hyperuricemia.

Methotrexate

Reduced renal tubular secretion of methotrexate, leading to increased plasma concentrations and potential toxicity.

Oral Contraceptives

May reduce the efficacy of oral contraceptives (rarely reported).

Warfarin and other oral anticoagulants

Increased risk of bleeding, monitor INR.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastrointestinal symptoms (nausea, vomiting, diarrhea) and fluid and electrolyte imbalance may occur. Renal impairment may lead to amoxicillin crystalluria. Treatment is symptomatic and supportive; hemodialysis can be used to remove amoxicillin from circulation.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus. Amoxicillin is excreted into breast milk in small amounts; generally considered safe during lactation, but monitor for potential adverse effects in the infant (e.g., diarrhea, candidiasis).

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 x 10 capsules (100 capsules in a box)1 x 10 capsules

Shelf Life

24 to 36 months from the date of manufacture, depending on manufacturer specifications.

Availability

Available in pharmacies and hospitals nationwide

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Amoxicillin has been extensively studied in numerous clinical trials since its introduction, demonstrating its efficacy and safety in treating a broad range of bacterial infections. Ongoing research focuses on resistance patterns and optimal dosing strategies.

Lab Monitoring

Renal function tests (e.g., creatinine, BUN) for prolonged therapy or in patients with pre-existing renal impairment.
Complete blood count (CBC) during prolonged therapy.

Doctor Notes

Ensure patient is not allergic to penicillins before prescribing.
Advise patients to complete the full course of treatment to prevent resistance.
Consider renal function adjustment in elderly and renally impaired patients.

Patient Guidelines

Take the medicine for the full prescribed duration, even if symptoms improve.
Do not share your medication with others.
Inform your doctor about any allergies, especially to penicillins or cephalosporins.
Report any severe side effects like rash, difficulty breathing, or severe diarrhea immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Amoxicillin generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or other side effects that impair your concentration, avoid these activities.