Adonid
Generic Name
Adonid
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adonid 500 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
Adonid 500 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is typically prescribed for conditions such as osteoarthritis, rheumatoid arthritis, menstrual pain, and mild to moderate pain.
Uses & Indications
Dosage
Adults
Oral: 500 mg once or twice daily, or as directed by a physician. Max dose: 1000 mg/day.
Elderly
Lower doses may be required; caution is advised due to increased risk of side effects, particularly renal and gastrointestinal complications.
Renal_impairment
Dosage adjustment may be necessary; use with caution. Not recommended for severe renal impairment (CrCl < 30 mL/min).
How to Take
Take Adonid 500 mg Tablet orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
Mechanism of Action
Adonid acts by inhibiting the enzyme cyclooxygenase (COX-1 and COX-2), which is responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever. By reducing prostaglandin production, Adonid effectively alleviates these symptoms.
Pharmacokinetics
Onset
30-60 minutes for analgesic effect.
Excretion
Excreted mainly via the kidneys (urine) as metabolites and unchanged drug; a small amount is excreted in feces.
Half life
Approximately 2-4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (e.g., CYP2C9) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Adonid or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Drug Interactions
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects; increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE inhibitors/Angiotensin II receptor blockers (ARBs)
Increased risk of renal impairment and reduced antihypertensive effect.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. More severe cases may involve renal dysfunction, respiratory depression, and coma. Management is symptomatic and supportive. Gastric lavage or activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C (D in 3rd trimester). Avoid use in the third trimester of pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use with caution in other trimesters if benefits outweigh risks. Not recommended during breastfeeding as Adonid may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Adonid or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Drug Interactions
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects; increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE inhibitors/Angiotensin II receptor blockers (ARBs)
Increased risk of renal impairment and reduced antihypertensive effect.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. More severe cases may involve renal dysfunction, respiratory depression, and coma. Management is symptomatic and supportive. Gastric lavage or activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C (D in 3rd trimester). Avoid use in the third trimester of pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use with caution in other trimesters if benefits outweigh risks. Not recommended during breastfeeding as Adonid may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Under patent
Clinical Trials
Adonid has undergone extensive Phase I, II, and III clinical trials demonstrating its efficacy and safety profile for various pain and inflammatory conditions. Post-marketing surveillance continues to monitor long-term effects.
Lab Monitoring
- Complete Blood Count (CBC) (especially for long-term use)
- Renal function tests (e.g., creatinine, BUN)
- Liver function tests (e.g., ALT, AST)
Doctor Notes
- Educate patients on the signs and symptoms of GI bleeding and cardiovascular events.
- Monitor renal function, blood pressure, and liver enzymes periodically, especially in elderly patients or those with pre-existing conditions.
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Patient Guidelines
- Always take Adonid exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Report any unusual symptoms, especially stomach pain, black stools, or persistent headache, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Adonid may cause dizziness, drowsiness, or visual disturbances in some individuals. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid alcohol and smoking, as they can increase the risk of gastrointestinal adverse effects.
- Limit intake of spicy and fatty foods to reduce stomach irritation.
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International brand names for this medicine. Click a brand to search for detailed information.