Administer by oral inhalation using a metered-dose inhaler. Rinse mouth after each use to prevent oral thrush.

Salmeterol is a long-acting beta-2 adrenergic receptor agonist that relaxes bronchial smooth muscle. Fluticasone propionate is a corticosteroid that reduces inflammation in the lungs.

• •Hypersensitivity to salmeterol, fluticasone, or any component of the formulation.
• •Primary treatment of status asthmaticus or other acute episodes of COPD where intensive measures are required.

Store at room temperature, away from direct sunlight and heat.

Symptoms of salmeterol overdose include tachycardia, tremor, headache, and hypokalemia. Symptoms of fluticasone overdose include adrenal suppression, Cushing's syndrome, and decreased bone mineral density. Treatment is supportive and symptomatic.

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing woman.