AirPro
Generic Name
Formoterol Fumarate
Manufacturer
PharmaCo Bangladesh Ltd.
Country
Bangladesh
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Description
Overview of the medicine
AirPro (Formoterol Fumarate) is a long-acting beta-2 adrenergic agonist (LABA) used for the long-term maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD). It helps to relax the muscles around the airways, making it easier to breathe. It is not intended for acute relief of bronchospasm.
Uses & Indications
Dosage
Adults
For asthma and COPD: 12 mcg (2 inhalations of 6 mcg) twice daily. For EIB: 12 mcg (2 inhalations of 6 mcg) at least 15 minutes before exercise; do not exceed 2 doses per 24 hours.
Elderly
No dosage adjustment specifically required, but use with caution due to potential increased sensitivity.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
For oral inhalation only. Patients should be instructed on the proper use of the inhaler device. Do not swallow. Rinse mouth with water after each use to reduce the risk of oral candidiasis.
Mechanism of Action
Formoterol selectively stimulates beta-2 adrenergic receptors in the bronchial smooth muscle, leading to bronchodilation. It acts intracellularly to activate adenylyl cyclase, which catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle and inhibit the release of mediators from mast cells in the airways.
Pharmacokinetics
Onset
Within 1-3 minutes after inhalation.
Excretion
Mainly via urine (60%) and feces (32%) over 6-8 days.
Half life
Approximately 10-14 hours (terminal half-life).
Absorption
Rapidly absorbed after oral inhalation; peak plasma concentrations reached within 5-10 minutes. Absolute bioavailability is approximately 10%.
Metabolism
Primarily metabolized in the liver via direct glucuronidation and O-demethylation, followed by glucuronidation.
Side Effects
Contraindications
- Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required.
- Hypersensitivity to formoterol or any component of the formulation.
Drug Interactions
Beta-blockers
May blunt the pulmonary effect of AirPro. Avoid concomitant use unless benefits outweigh risks.
QTc-prolonging drugs
Increased risk of ventricular arrhythmias. Use with caution.
Diuretics (loop or thiazide)
May potentiate hypokalemia and ECG changes, especially in concomitant hypoxemia. Use with caution.
MAO Inhibitors, Tricyclic Antidepressants
May potentiate the effect of AirPro on the cardiovascular system. Use with extreme caution.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include excessive beta-adrenergic stimulation (e.g., tachycardia, palpitations, tremor, headache, nausea, vomiting, hypokalemia, hyperglycemia). Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether formoterol is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required.
- Hypersensitivity to formoterol or any component of the formulation.
Drug Interactions
Beta-blockers
May blunt the pulmonary effect of AirPro. Avoid concomitant use unless benefits outweigh risks.
QTc-prolonging drugs
Increased risk of ventricular arrhythmias. Use with caution.
Diuretics (loop or thiazide)
May potentiate hypokalemia and ECG changes, especially in concomitant hypoxemia. Use with caution.
MAO Inhibitors, Tricyclic Antidepressants
May potentiate the effect of AirPro on the cardiovascular system. Use with extreme caution.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include excessive beta-adrenergic stimulation (e.g., tachycardia, palpitations, tremor, headache, nausea, vomiting, hypokalemia, hyperglycemia). Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether formoterol is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA and FDA
Patent Status
Generic versions available
WHO Essential Medicine
YesClinical Trials
Formoterol fumarate has been extensively studied in clinical trials demonstrating its efficacy and safety in the long-term management of asthma and COPD, often in combination with inhaled corticosteroids. Key trials established its bronchodilatory effects and safety profile.
Lab Monitoring
- Serum potassium levels (especially in patients at risk of hypokalemia)
- Blood glucose levels (in diabetic patients)
Doctor Notes
- Emphasize that AirPro is for maintenance, not for acute symptoms.
- Instruct patients to always use AirPro with an inhaled corticosteroid for asthma.
- Educate on proper inhaler technique and rinsing mouth after use.
- Monitor for signs of cardiovascular effects, hypokalemia, or worsening asthma.
Patient Guidelines
- Use AirPro exactly as prescribed by your doctor. Do not exceed the recommended dose.
- AirPro is a long-term maintenance medicine and should not be used for sudden breathing problems.
- If your breathing problems worsen or your short-acting rescue inhaler does not work as usual, seek immediate medical attention.
- Always use AirPro with an inhaled corticosteroid for asthma management.
- Rinse your mouth with water after each use to help prevent oral fungal infections.
Missed Dose Advice
If a dose is missed, take the next dose at the regularly scheduled time. Do not take a double dose to make up for a missed one.
Driving Precautions
AirPro may cause dizziness or tremor in some patients. If these symptoms occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid known triggers for your asthma or COPD (e.g., smoke, allergens, air pollution).
- Maintain a healthy lifestyle, including regular exercise (as tolerated) and a balanced diet.
- Quit smoking to significantly improve respiratory health.
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International brand names for this medicine. Click a brand to search for detailed information.
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