Alafex
Generic Name
alafix
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Alafex (alafix) is a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria. It provides effective relief from sneezing, runny nose, itchy eyes/nose/throat, and skin itching.
Uses & Indications
Dosage
Adults
120 mg or 180 mg once daily.
Elderly
No specific dose adjustment recommended for elderly patients with normal renal function.
Renal_impairment
For adults with impaired renal function, a starting dose of 60 mg once daily is recommended.
How to Take
Alafex tablets should be taken orally with water. It can be taken with or without food, but avoid taking with fruit juice (e.g., grapefruit, orange, apple) as it may reduce absorption.
Mechanism of Action
alafix is a selective peripheral H1-receptor antagonist. It binds to H1 receptors and prevents the actions of histamine, thereby reducing allergic symptoms without causing significant central nervous system effects like drowsiness.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Primarily excreted unchanged in feces (80%) and urine (11%).
Half life
Approximately 14 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in 1-3 hours.
Metabolism
Minimally metabolized; primarily by CYP450 enzymes in the liver to a minor extent.
Side Effects
Contraindications
- Hypersensitivity to alafix or any excipients.
- Children under 6 years of age.
Drug Interactions
Erythromycin, Ketoconazole
May increase alafix plasma concentrations.
Antacids containing aluminum or magnesium
May decrease alafix absorption; separate administration by at least 2 hours.
Storage
Store in a cool, dry place, below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. In case of an overdose, contact a physician or poison control center immediately. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Alafex should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether alafix is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have been conducted worldwide, demonstrating alafix's efficacy and safety in the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria across various age groups. Post-marketing surveillance continues to affirm its favorable safety profile.
Lab Monitoring
- Generally, no specific lab monitoring is required for patients taking alafix. However, if symptoms persist or worsen, further investigation may be warranted.
Doctor Notes
- Counsel patients to avoid fruit juices while taking Alafex.
- Monitor for symptom relief and potential side effects.
- Advise on proper storage.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medicine.
- Store in a cool, dry place.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Alafex is generally non-sedating, but individual responses can vary. Patients should assess their ability to drive or operate machinery before engaging in such activities.
Lifestyle Advice
- Identify and avoid known allergens.
- Keep windows closed during high pollen count days.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.