Alben-DS
Generic Name
Albendazole
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alben ds 400 mg chewable tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Albendazole is an anthelmintic medication used to treat a variety of parasitic worm infections. The 400 mg chewable tablet is commonly used for single-dose treatment of intestinal helminthiasis.
Uses & Indications
Dosage
Adults
For common intestinal worm infections (e.g., ascariasis, hookworm, pinworm, trichuriasis): 400 mg as a single dose.
Elderly
No specific dose adjustment generally needed, but caution in patients with hepatic impairment.
Renal_impairment
No dosage adjustment necessary.
How to Take
The tablet should be chewed or crushed and swallowed with water, preferably after a meal.
Mechanism of Action
Albendazole acts by inhibiting microtubule polymerization in susceptible helminths by binding to beta-tubulin, leading to impaired glucose uptake and depletion of glycogen stores, resulting in the worm's death.
Pharmacokinetics
Onset
Variable, depending on the worm type and location.
Excretion
Primarily via urine as metabolites; a small amount is excreted in bile.
Half life
Albendazole sulfoxide (active metabolite) has a plasma half-life of about 8-12 hours.
Absorption
Poorly absorbed from the gastrointestinal tract (less than 5%); absorption is increased with a fatty meal.
Metabolism
Rapidly and extensively metabolized in the liver to albendazole sulfoxide (active) and other metabolites.
Side Effects
Contraindications
- Hypersensitivity to albendazole or any component
- Pregnancy (especially first trimester)
Drug Interactions
Cimetidine, Dexamethasone, Praziquantel
May increase plasma levels of albendazole sulfoxide.
Ritonavir, Phenytoin, Carbamazepine, Phenobarbital
May decrease plasma levels of albendazole sulfoxide.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be initiated. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should not be used in pregnant women, particularly during the first trimester, unless the potential benefit justifies the potential risk to the fetus. Women of childbearing potential should use effective contraception during and for one month after treatment. Excreted in breast milk, use with caution in lactating mothers.
Side Effects
Contraindications
- Hypersensitivity to albendazole or any component
- Pregnancy (especially first trimester)
Drug Interactions
Cimetidine, Dexamethasone, Praziquantel
May increase plasma levels of albendazole sulfoxide.
Ritonavir, Phenytoin, Carbamazepine, Phenobarbital
May decrease plasma levels of albendazole sulfoxide.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be initiated. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should not be used in pregnant women, particularly during the first trimester, unless the potential benefit justifies the potential risk to the fetus. Women of childbearing potential should use effective contraception during and for one month after treatment. Excreted in breast milk, use with caution in lactating mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years
Availability
Pharmacies, Drugstores
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have been conducted for albendazole, supporting its efficacy and safety as an anthelmintic agent.
Lab Monitoring
- For short-term single-dose treatment, usually not required. For prolonged systemic treatments, regular monitoring of liver function tests and complete blood count is recommended.
Doctor Notes
- Advise patients on proper hygiene to prevent re-infection.
- For systemic infections, ensure appropriate monitoring of liver enzymes and blood counts.
- Avoid in early pregnancy.
Patient Guidelines
- Chew the tablet completely before swallowing or crush it.
- Take with food for better absorption.
- Complete the full course of treatment as prescribed.
- Wash hands thoroughly to prevent re-infection.
Missed Dose Advice
As this is often a single-dose treatment, take the dose as soon as remembered if it was missed entirely. If it's part of a multi-day regimen, consult your doctor.
Driving Precautions
Albendazole can cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hygiene practices to prevent re-infection, such as hand washing, proper food preparation, and clean sanitation.
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Global Brand Names
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