Albiquin
Generic Name
Quinine Sulfate
Manufacturer
Popular Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| albiquin 300 mg tablet | ৳ 6.40 | ৳ 64.00 |
Description
Overview of the medicine
Albiquin 300 mg Tablet contains Quinine Sulfate, an antimalarial drug used to treat uncomplicated P. falciparum malaria, especially in areas where other antimalarials may be less effective.
Uses & Indications
Dosage
Adults
600 mg (two 300 mg tablets) every 8 hours for 3-7 days, depending on clinical response and regional guidelines. Always use in combination with a second antimalarial.
Elderly
No specific dose adjustment for elderly patients with normal renal and hepatic function, but caution is advised due to potential for reduced organ function.
Renal_impairment
Dose reduction may be necessary in severe renal impairment (creatinine clearance < 20 mL/min). Consult physician.
How to Take
Take tablets orally with food or milk to minimize gastrointestinal irritation. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Quinine's primary mechanism of action involves inhibiting nucleic acid synthesis, protein synthesis, and glycolysis in the malaria parasite. It also intercalates into the parasite's DNA, preventing replication and transcription. It's a blood schizonticide, effective against erythrocytic forms of Plasmodium parasites.
Pharmacokinetics
Onset
Within 1-3 hours.
Excretion
Mainly excreted in urine (about 20% as unchanged drug, remainder as metabolites).
Half life
Approximately 10-18 hours; can be shorter in children and longer in severe malaria or hepatic impairment.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-3 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4, to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to quinine or other cinchona alkaloids
- Tinnitus, optic neuritis
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency (relative contraindication)
- Myasthenia gravis
- History of blackwater fever
- QT prolongation or risk factors for Torsade de Pointes
Drug Interactions
Warfarin
Quinine may enhance the anticoagulant effect of warfarin.
Cimetidine
May inhibit quinine metabolism, increasing its plasma concentrations.
Mefloquine
Increased risk of seizures and cardiac effects if given concurrently or too close together.
Cardiac glycosides (e.g., Digoxin)
Quinine can increase digoxin levels.
Antacids containing aluminum or magnesium
May delay or decrease absorption of quinine.
CYP3A4 inducers (e.g., Rifampicin, Carbamazepine)
May decrease quinine levels.
CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase quinine levels.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include cinchonism (tinnitus, headache, nausea, blurred vision, dizziness), severe cardiovascular effects (arrhythmias, hypotension), central nervous system depression, convulsions, and respiratory depression. Treatment is supportive, including gastric lavage, activated charcoal, and symptomatic management of cardiac and CNS effects. Close monitoring is essential.
Pregnancy & Lactation
Pregnancy Category D. Quinine crosses the placenta and can cause fetal hearing loss or other congenital anomalies in high doses, but it is considered acceptable for treating severe malaria during pregnancy if no safer alternatives are available. Excreted into breast milk in small amounts; generally considered compatible with breastfeeding when used at therapeutic doses for malaria, but observe infant for side effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (DGDA)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Quinine has been used for malaria treatment for centuries; its efficacy is well-established. Modern clinical trials often focus on combination therapies or resistance patterns, rather than quinine as a monotherapy for uncomplicated malaria.
Lab Monitoring
- Baseline and regular blood glucose levels (especially in severe malaria or those at risk of hypoglycemia)
- Complete blood count (CBC) if prolonged use or suspected hematologic toxicity
- Liver function tests (LFTs) if hepatic impairment is suspected
- Renal function tests (RFTs) if renal impairment is suspected or to guide dosing
- ECG monitoring in patients with pre-existing cardiac conditions or risk factors for QT prolongation
Doctor Notes
- Emphasize adherence to the full treatment course.
- Monitor for signs of cinchonism and manage symptomatically.
- Caution in patients with cardiac arrhythmias or G6PD deficiency.
- Not for prevention of nocturnal leg cramps due to risk-benefit profile.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and complete the full course.
- Always take with food or milk to reduce stomach upset.
- Be aware of symptoms of cinchonism and report them to your doctor.
- Avoid driving or operating machinery if you experience dizziness or blurred vision.
- Do not stop taking the medicine suddenly without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for the next dose. Do not take a double dose to make up for a missed one. Contact your doctor or pharmacist for advice.
Driving Precautions
Albiquin can cause dizziness, blurred vision, and headache (cinchonism). Patients should be advised to avoid driving or operating heavy machinery if these symptoms occur.
Lifestyle Advice
- Stay hydrated, especially if experiencing fever or vomiting.
- Avoid excessive sun exposure due to potential photosensitivity.
- Ensure adequate rest to support recovery from malaria.
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Global Brand Names
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