Alcasol
Generic Name
alcasol-1500-mg-oral-solution
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alcasol 1500 mg oral solution | ৳ 200.00 | N/A |
Description
Overview of the medicine
Alcasol 1500 mg Oral Solution is used to make urine less acidic, helping to prevent certain types of kidney stones (calcium oxalate, uric acid). It works by increasing urinary citrate, which binds with calcium and inhibits crystal formation.
Uses & Indications
Dosage
Adults
The typical adult dose is 10-30 mEq (equivalent to Alcasol 1500 mg) diluted in 6 ounces of water, 3-4 times daily with meals or within 30 minutes after meals or bedtime snack. Dosage should be adjusted based on urinary pH and stone type.
Elderly
No specific dosage adjustment is generally required for elderly patients, but renal function should be monitored due to age-related decline in kidney function.
Renal_impairment
Contraindicated in severe renal impairment. Use with caution in mild to moderate renal impairment with close monitoring of serum potassium levels.
How to Take
Alcasol 1500 mg Oral Solution should be diluted in a full glass (approx. 6 ounces) of water or juice. Take orally with meals or within 30 minutes after meals or a bedtime snack to minimize potential gastrointestinal upset. Drink plenty of fluids throughout the day.
Mechanism of Action
The citrate in Alcasol is metabolized to bicarbonate, which increases urinary pH, making the urine less acidic. This increased alkalinity helps to prevent the crystallization of stone-forming salts like calcium oxalate and uric acid. Citrate also binds with calcium in the urine, reducing the supersaturation of calcium oxalate and inhibiting stone formation.
Pharmacokinetics
Onset
Urinary alkalinization typically begins within 30-60 minutes after oral administration.
Excretion
Primarily excreted via the kidneys, with a small portion excreted unchanged in urine.
Half life
The half-life of citrate is short, usually around 30-50 minutes.
Absorption
Rapidly absorbed from the gastrointestinal tract.
Metabolism
Citrate is extensively metabolized in the liver to bicarbonate.
Side Effects
Contraindications
- Severe renal impairment (glomerular filtration rate < 0.7 ml/min/kg).
- Untreated Addison's disease.
- Hyperkalemia (or conditions predisposing to hyperkalemia such as uncontrolled diabetes mellitus).
- Active urinary tract infection.
- Peptic ulcer disease.
- Obstructed urinary tract.
Drug Interactions
NSAIDs
May increase the risk of gastrointestinal irritation and hyperkalemia.
ACE Inhibitors/ARBs
Increased risk of hyperkalemia.
Potassium-sparing diuretics
Concurrent use may lead to severe hyperkalemia.
Antacids containing aluminum
May reduce the absorption of citrate.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Overdose may lead to hyperkalemia and/or severe gastrointestinal irritation. Symptoms of hyperkalemia include muscle weakness, tingling sensations, and abnormal heart rhythm. Treatment involves discontinuing the drug, administering IV calcium gluconate for cardiac effects, and possibly insulin and glucose for potassium shift. Hemodialysis may be required in severe cases.
Pregnancy & Lactation
There are no adequate and well-controlled studies in pregnant women. Use Alcasol during pregnancy or lactation only if clearly needed and the potential benefits outweigh the potential risks to the fetus or infant. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, depending on the specific product formulation and manufacturer.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Expired
Clinical Trials
Extensive clinical trials have established the efficacy of potassium citrate in preventing kidney stones. Ongoing research explores optimized dosing regimens and combination therapies for complex cases.
Lab Monitoring
- Serum potassium levels (regularly, especially at treatment initiation and dose changes).
- Renal function (serum creatinine, BUN).
- Urinary pH (to guide dosage adjustment).
- Electrolyte panel (sodium, chloride, bicarbonate).
Doctor Notes
- Emphasize the importance of dilution and administration with food to patients.
- Monitor serum potassium and renal function closely, especially in high-risk patients.
- Educate patients on symptoms of hyperkalemia and when to seek medical attention.
Patient Guidelines
- Always dilute the solution in a full glass of water or juice before taking.
- Take with or after meals to minimize stomach upset.
- Do not stop taking the medicine without consulting your doctor.
- Report any signs of severe abdominal pain, muscle weakness, or irregular heartbeat immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Alcasol 1500 mg Oral Solution is not known to impair the ability to drive or operate machinery. However, if you experience any side effects that affect your concentration or coordination, avoid such activities.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of water throughout the day.
- Follow any specific dietary recommendations given by your doctor to prevent kidney stones (e.g., low sodium, appropriate calcium intake).
- Avoid consuming excessive amounts of potassium-rich foods unless advised by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.