Aleena
Generic Name
Desloratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aleena 4 mg tablet | ৳ 400.00 | N/A |
Description
Overview of the medicine
Aleena 4 mg Tablet is an antihistamine used to relieve allergy symptoms such as sneezing, runny nose, watery eyes, and itching. It works by blocking histamine, a natural substance that the body makes during an allergic reaction. It is a non-drowsy formulation.
Uses & Indications
Dosage
Adults
One 4 mg tablet once daily.
Elderly
No specific dosage adjustment is generally required, but caution is advised due to potential age-related decrease in renal or hepatic function.
Renal_impairment
For severe renal impairment (creatinine clearance <30 mL/min), initial dose of 4 mg every other day is recommended.
How to Take
Take the tablet orally with or without food, usually once daily. Do not crush or chew the tablet.
Mechanism of Action
Desloratadine is a long-acting tricyclic antihistamine with selective H1-receptor antagonist activity. It prevents histamine from binding to H1 receptors, thereby inhibiting the effects of histamine such as vasodilation, increased capillary permeability, and itching.
Pharmacokinetics
Onset
Relief of symptoms typically occurs within 1 hour.
Excretion
Excreted in urine and feces, predominantly as metabolites.
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are achieved within approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, via hydroxylation. Metabolized by cytochrome P450 enzymes, though the specific isoenzymes are not fully characterized.
Side Effects
Contraindications
- •Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- •Severe renal or hepatic impairment (with caution and dose adjustment).
Drug Interactions
Cimetidine
May increase desloratadine plasma levels. Clinical significance usually minimal.
Erythromycin
May increase desloratadine plasma levels. Clinical significance usually minimal.
Ketoconazole
May increase desloratadine plasma levels. Clinical significance usually minimal.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Not recommended during breastfeeding as desloratadine is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory bodies worldwide, including FDA and DGDA.
Patent Status
Patent expired for generic Desloratadine
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Global Brand Names
International brand names for this medicine
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