alerfex
Generic Name
fexofenadine
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alerfex 30 mg suspension | ৳ 55.00 | N/A |
Description
Overview of the medicine
Alerfex 30 mg Suspension contains fexofenadine, a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria in children.
Uses & Indications
Dosage
Adults
This 30 mg suspension is primarily for pediatric use. For seasonal allergic rhinitis in children 2-11 years: 30 mg (5 mL) twice daily. For chronic idiopathic urticaria in children 6 months to 2 years: 15 mg (2.5 mL) twice daily; 2-11 years: 30 mg (5 mL) twice daily.
Elderly
No specific dose adjustment is generally required for elderly patients with normal renal function, but this strength/formulation is not typically used for adults or elderly.
Renal_impairment
For children 2-11 years with impaired renal function (CrCl ≤ 80 mL/min), the recommended initial dose is 30 mg (5 mL) once daily. For children 6 months to 2 years with renal impairment, 15 mg (2.5 mL) once daily.
How to Take
Shake the bottle well before each use. Administer orally using the provided measuring device. Can be taken with or without food.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It competitively binds to H1 receptors, preventing histamine from binding and exerting its effects, thereby reducing allergic symptoms.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted unchanged in feces (approximately 80%) and urine (approximately 11%).
Half life
Approximately 14.4 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 2-3 hours.
Metabolism
Minimally metabolized; approximately 5% of the total dose is metabolized.
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine or any component of the suspension.
- Not recommended for children under 6 months.
Drug Interactions
Erythromycin and Ketoconazole
May increase fexofenadine plasma concentrations. Monitor for increased side effects.
Antacids containing aluminum or magnesium
May decrease fexofenadine absorption. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms may include dizziness, drowsiness, and dry mouth. Management involves symptomatic and supportive treatment. Gastric lavage may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted in human milk, use with caution during lactation.
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine or any component of the suspension.
- Not recommended for children under 6 months.
Drug Interactions
Erythromycin and Ketoconazole
May increase fexofenadine plasma concentrations. Monitor for increased side effects.
Antacids containing aluminum or magnesium
May decrease fexofenadine absorption. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms may include dizziness, drowsiness, and dry mouth. Management involves symptomatic and supportive treatment. Gastric lavage may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted in human milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months. Refer to the specific product label for exact shelf life.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have established the efficacy and safety of fexofenadine across various allergic conditions in pediatric and adult populations.
Lab Monitoring
- No specific routine lab monitoring required for fexofenadine in healthy individuals. Periodic monitoring of renal function may be considered in patients with pre-existing renal impairment.
Doctor Notes
- Advise parents on proper measurement and administration techniques for the suspension.
- Reinforce the non-sedating nature but caution about individual variability in response.
- Consider renal function in pediatric patients requiring treatment, adjusting dosage as necessary.
Patient Guidelines
- Do not exceed the recommended dose.
- Report any unusual side effects to your doctor.
- Avoid consuming fruit juices close to the time of taking this medicine.
- Shake the bottle well before each use.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Fexofenadine is generally non-sedating, but individual responses vary. Patients should assess their response before driving or operating machinery, especially when starting treatment.
Lifestyle Advice
- Avoid known allergens to help manage symptoms.
- Maintain good hydration.
- Ensure adequate rest to support recovery from allergic reactions.
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