Alergix-MR
Generic Name
Desloratadine + Montelukast
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alergix mr 10 mg tablet | ৳ 6.50 | ৳ 65.00 |
Description
Overview of the medicine
Alergix-MR is a combination medicine containing Desloratadine, an antihistamine, and Montelukast, a leukotriene receptor antagonist. It is used to relieve symptoms of allergic rhinitis and to prevent and treat chronic asthma.
Uses & Indications
Dosage
Adults
One tablet (Desloratadine 5 mg + Montelukast 10 mg) once daily, preferably in the evening.
Elderly
No specific dose adjustment is generally required, but caution is advised in patients with severe renal or hepatic impairment.
Renal_impairment
Use with caution. For severe renal impairment, dose adjustment or increased dosing interval may be considered for Desloratadine. Montelukast generally does not require adjustment.
How to Take
Take orally with or without food, preferably in the evening.
Mechanism of Action
Desloratadine is a potent, selective peripheral H1-receptor antagonist that provides non-sedating antihistamine activity. Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene CysLT1 receptor, thereby reducing inflammatory effects.
Pharmacokinetics
Onset
Desloratadine: within 30 minutes; Montelukast: within 1 day for chronic effects.
Excretion
Desloratadine is excreted equally in urine and feces as metabolic products. Montelukast and its metabolites are primarily excreted in the feces via the bile.
Half life
Desloratadine: approximately 27 hours; Montelukast: 2.7 to 5.5 hours.
Absorption
Desloratadine is well absorbed, reaching peak plasma concentrations in approximately 3 hours. Montelukast is rapidly absorbed after oral administration, with peak plasma concentrations achieved in 2-4 hours for film-coated tablets.
Metabolism
Desloratadine is extensively metabolized to 3-hydroxydesloratadine. Montelukast is extensively metabolized in the liver by CYP2C8, 3A4, and 2C9.
Side Effects
Contraindications
- Hypersensitivity to Desloratadine, Montelukast, or any component of the tablet
- Severe liver disease (for Montelukast)
- Acute asthma attacks (Montelukast is not for acute relief)
Drug Interactions
Gemfibrozil
May increase Montelukast plasma concentrations.
Phenobarbital, Rifampicin
May decrease plasma concentration of Montelukast.
Ketoconazole, Erythromycin, Fluoxetine
May increase plasma concentration of Desloratadine.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of Desloratadine overdose may include somnolence, increased heart rate, and headache. Montelukast overdose symptoms are generally mild and may include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus/infant. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to Desloratadine, Montelukast, or any component of the tablet
- Severe liver disease (for Montelukast)
- Acute asthma attacks (Montelukast is not for acute relief)
Drug Interactions
Gemfibrozil
May increase Montelukast plasma concentrations.
Phenobarbital, Rifampicin
May decrease plasma concentration of Montelukast.
Ketoconazole, Erythromycin, Fluoxetine
May increase plasma concentration of Desloratadine.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of Desloratadine overdose may include somnolence, increased heart rate, and headache. Montelukast overdose symptoms are generally mild and may include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus/infant. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Desloratadine and Montelukast both individually and in combination for allergic rhinitis and asthma management.
Lab Monitoring
- No specific routine lab monitoring is generally required for healthy individuals. Liver function tests may be considered in patients with pre-existing hepatic impairment or if symptoms suggest liver dysfunction.
Doctor Notes
- Emphasize that this is a prophylactic and maintenance treatment, not for acute relief.
- Advise patients to report any neuropsychiatric symptoms immediately.
Patient Guidelines
- Take the tablet whole, do not crush or chew.
- Take it once daily, preferably in the evening.
- Do not stop taking the medicine suddenly without consulting your doctor, especially for asthma.
- This medicine is not for acute asthma attacks; use your rescue inhaler for sudden breathing difficulties.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause drowsiness in some individuals. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid known allergens that trigger your symptoms.
- Maintain a healthy lifestyle to support overall respiratory health.
- Regular exercise, but use prophylactic measures if you have exercise-induced asthma.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.