Alervil
Generic Name
Alervil-15-mg-syrup
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alervil 15 mg syrup | ৳ 25.00 | N/A |
Description
Overview of the medicine
Alervil 15 mg Syrup is an antihistamine used to relieve allergy symptoms such as sneezing, runny nose, watery eyes, and itching. It contains Desloratadine, a non-drowsy formulation.
Uses & Indications
Dosage
Adults
5 mg (approximately 3.3 mL of syrup) once daily
Elderly
No specific dose adjustment required, but caution with renal/hepatic impairment. Typically 5 mg (approximately 3.3 mL of syrup) once daily.
Renal_impairment
Initial dose of 5 mg (approximately 3.3 mL of syrup) every other day for moderate to severe impairment.
How to Take
May be taken with or without food. Administer orally using a measuring spoon or oral syringe.
Mechanism of Action
Desloratadine, the active metabolite of loratadine, is a non-sedating, long-acting histamine antagonist with selective peripheral H1-receptor antagonist activity. It inhibits the release of histamine from mast cells and reduces inflammatory mediators.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted in urine and feces as metabolites.
Half life
Approximately 27 hours
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in approximately 3 hours.
Metabolism
Undergoes extensive metabolism in the liver to 3-hydroxydesloratadine, an active metabolite, via cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Desloratadine, Loratadine, or any component of the formulation
- Severe renal impairment (use with caution)
Drug Interactions
Cimetidine
May increase plasma concentrations of desloratadine.
Fluoxetine
May increase plasma concentrations of desloratadine.
Erythromycin
May increase plasma concentrations of desloratadine.
Ketoconazole
May increase plasma concentrations of desloratadine.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, and headache. In case of overdose, initiate symptomatic and supportive treatment. Desloratadine is not removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, so use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to Desloratadine, Loratadine, or any component of the formulation
- Severe renal impairment (use with caution)
Drug Interactions
Cimetidine
May increase plasma concentrations of desloratadine.
Fluoxetine
May increase plasma concentrations of desloratadine.
Erythromycin
May increase plasma concentrations of desloratadine.
Ketoconazole
May increase plasma concentrations of desloratadine.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, and headache. In case of overdose, initiate symptomatic and supportive treatment. Desloratadine is not removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, so use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Directorate General of Drug Administration, Bangladesh)
Patent Status
Generic available, patent expired for active ingredient
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of desloratadine for allergic rhinitis and chronic idiopathic urticaria in adults and pediatric populations.
Lab Monitoring
- No specific laboratory monitoring required for routine use. Liver function tests may be considered in patients with pre-existing hepatic impairment.
Doctor Notes
- Advise patients to report any unusual side effects.
- Counsel on the importance of consistent dosing for optimal relief.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Store at room temperature away from light and moisture.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Although Alervil is generally non-sedating, individuals should be cautious when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Avoid alcohol consumption as it may increase drowsiness.
- Stay hydrated by drinking plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.