Alfil
Generic Name
Sildenafil Citrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alfil capsule | ৳ 3.00 | N/A |
Description
Overview of the medicine
Alfil (Sildenafil Citrate) is a medication used to treat erectile dysfunction (impotence) in men and pulmonary arterial hypertension.
Uses & Indications
Dosage
Adults
For Erectile Dysfunction: 50 mg as needed, 1 hour before sexual activity. Max dose 100mg. Max frequency: once daily. For Pulmonary Hypertension: 20 mg three times daily.
Elderly
Initiate at lower doses (e.g., 25 mg) due to potential for age-related decreased renal and hepatic function.
Renal_impairment
Mild to moderate impairment: No dosage adjustment needed. Severe impairment: Initiate at 25 mg.
How to Take
Oral administration, with or without food. Avoid high-fat meals as they may delay absorption.
Mechanism of Action
Sildenafil inhibits PDE5, which increases cGMP levels in the corpus cavernosum, leading to smooth muscle relaxation and increased blood flow to the penis.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Fecal excretion (80%) and urinary excretion (13%).
Half life
Approximately 4 hours.
Absorption
Rapidly absorbed after oral administration; bioavailability ~40%.
Metabolism
Primarily hepatic via CYP3A4 and CYP2C9.
Side Effects
Contraindications
- Concurrent use with nitrates
- Known hypersensitivity to sildenafil or any of the excipients
Drug Interactions
Nitrates
Severe hypotension; contraindicated.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
Increased sildenafil plasma levels; dosage adjustment may be needed.
Storage
Store at room temperature (15-30°C) away from moisture and light.
Overdose
Supportive measures; dialysis is unlikely to be effective due to high protein binding.
Pregnancy & Lactation
Not indicated for use in women. Category B (Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women).
Side Effects
Contraindications
- Concurrent use with nitrates
- Known hypersensitivity to sildenafil or any of the excipients
Drug Interactions
Nitrates
Severe hypotension; contraindicated.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
Increased sildenafil plasma levels; dosage adjustment may be needed.
Storage
Store at room temperature (15-30°C) away from moisture and light.
Overdose
Supportive measures; dialysis is unlikely to be effective due to high protein binding.
Pregnancy & Lactation
Not indicated for use in women. Category B (Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years
Availability
Pharmacies and online retailers
Approval Status
DGDA Approved
Patent Status
Off-Patent
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of sildenafil for the treatment of erectile dysfunction and pulmonary arterial hypertension.
Lab Monitoring
- Blood pressure monitoring
- Visual acuity (if visual disturbances occur)
Doctor Notes
- Assess cardiovascular risk before prescribing sildenafil.
- Counsel patients about potential side effects and drug interactions.
Patient Guidelines
- Take as directed by your physician.
- Inform your doctor of all medications you are taking.
- Seek immediate medical attention if you experience chest pain or priapism.
Missed Dose Advice
For Erectile Dysfunction: Take only as needed, so a missed dose is not relevant. For Pulmonary Hypertension: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or visual disturbances; exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy lifestyle, including regular exercise and a balanced diet.
- Limit alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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