Alflam
Generic Name
Diclofenac Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alflam 400 mg tablet | ৳ 1.42 | ৳ 14.20 |
Description
Overview of the medicine
Alflam 400 mg Tablet contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation in various conditions.
Uses & Indications
Dosage
Adults
Typically, the dosage of Diclofenac varies from 75 mg to 150 mg daily, divided into 2-3 doses. For Alflam 400 mg tablet, one tablet once daily or as advised by physician for specific conditions requiring higher doses, considering individual patient needs and tolerability.
Elderly
Lower doses may be required due to increased sensitivity to adverse effects and potential impaired renal function. Use with caution.
Renal_impairment
Use with caution in patients with mild to moderate renal impairment. Dose adjustment may be necessary. Contraindicated in severe renal impairment.
How to Take
Take the tablet orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
Mechanism of Action
Diclofenac works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever.
Pharmacokinetics
Onset
Analgesic effect begins within 30-60 minutes.
Excretion
Approximately 60% of the dose is excreted in the urine as metabolites, and 30-40% is excreted in the bile.
Half life
Plasma elimination half-life is approximately 1-2 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, though rate may vary with food. Peak plasma concentrations are achieved within 2-3 hours.
Metabolism
Extensively metabolized in the liver by hydroxylation and glucuronidation, primarily by CYP2C9.
Side Effects
Contraindications
- •Known hypersensitivity to diclofenac or any NSAID (e.g., aspirin-induced asthma, urticaria)
- •Active gastrointestinal bleeding or peptic ulcer disease
- •Severe renal or hepatic impairment
- •Severe heart failure (NYHA Class III-IV)
- •Third trimester of pregnancy
- •Coronary Artery Bypass Graft (CABG) surgery perioperative pain
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effects; risk of renal impairment increased.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In severe cases, acute renal failure, respiratory depression, and coma may occur. Management involves gastric lavage, activated charcoal, and symptomatic and supportive treatment. There is no specific antidote.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to potential fetal cardiovascular effects. Use in the first and second trimesters and during lactation only if the potential benefit outweighs the potential risk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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