Alia
Generic Name
Desloratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alia 5 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Alia 5 mg tablet contains Desloratadine, a non-drowsy antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives.
Uses & Indications
Dosage
Adults
The recommended dose for adults and adolescents 12 years of age and older is 5 mg (one tablet) once daily.
Elderly
No dosage adjustment is generally required for elderly patients, but caution should be exercised in those with renal or hepatic impairment.
Renal_impairment
For patients with severe renal impairment, a starting dose of 5 mg every other day is recommended.
How to Take
Alia 5 mg tablet can be taken with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Desloratadine is a potent, long-acting, selective peripheral histamine H1-receptor antagonist. It inhibits the release of histamine from mast cells and basophils, thereby suppressing the allergic reaction.
Pharmacokinetics
Onset
Onset of action typically occurs within 30 minutes to 1 hour.
Excretion
Excreted almost equally via urine and feces as metabolites.
Half life
Mean plasma elimination half-life is approximately 27 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations reached within approximately 3 hours.
Metabolism
Extensively metabolized, primarily to 3-hydroxydesloratadine, which is an active metabolite. Metabolism involves CYP3A4 (minor) and UGTs.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or to any of the excipients.
Drug Interactions
Cimetidine
Increased plasma concentrations of desloratadine reported, but no clinically significant adverse effects.
Fluoxetine
Increased plasma concentrations of desloratadine reported, but no clinically significant adverse effects.
Erythromycin
Increased plasma concentrations of desloratadine reported, but no clinically significant adverse effects.
Ketoconazole
Increased plasma concentrations of desloratadine reported, but no clinically significant adverse effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep all medicines out of the reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment is recommended. Desloratadine is not eliminated by hemodialysis.
Pregnancy & Lactation
Desloratadine is categorized as Pregnancy Category C. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or to any of the excipients.
Drug Interactions
Cimetidine
Increased plasma concentrations of desloratadine reported, but no clinically significant adverse effects.
Fluoxetine
Increased plasma concentrations of desloratadine reported, but no clinically significant adverse effects.
Erythromycin
Increased plasma concentrations of desloratadine reported, but no clinically significant adverse effects.
Ketoconazole
Increased plasma concentrations of desloratadine reported, but no clinically significant adverse effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep all medicines out of the reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment is recommended. Desloratadine is not eliminated by hemodialysis.
Pregnancy & Lactation
Desloratadine is categorized as Pregnancy Category C. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent Expired
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of desloratadine in treating allergic rhinitis and chronic idiopathic urticaria, showing rapid onset of action and sustained symptom relief with a favorable tolerability profile.
Lab Monitoring
- Routine laboratory monitoring is generally not required for desloratadine. In rare cases of suspected liver dysfunction, liver function tests (LFTs) may be considered.
Doctor Notes
- Advise patients on proper administration and adherence to the once-daily dosage.
- Counsel on potential mild drowsiness and caution for driving/operating machinery.
- Consider dosage adjustment in patients with severe renal impairment.
- Review patient's medical history for any contraindications or potential drug interactions.
Patient Guidelines
- Take one tablet daily, preferably at the same time each day.
- Do not exceed the recommended dose.
- If symptoms do not improve or worsen, consult your doctor.
- Keep out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Desloratadine does not typically cause significant drowsiness; however, individual responses may vary. Patients should be advised to exercise caution when driving or operating machinery until they know how they react to the medicine.
Lifestyle Advice
- Avoid driving or operating machinery if you experience drowsiness.
- Avoid alcohol consumption as it may enhance the sedative effect.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.