Alinix
Generic Name
Alinofloxacin
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alinix 500 mg tablet | ৳ 10.00 | ৳ 60.00 |
Description
Overview of the medicine
Alinix 500 mg Tablet is a broad-spectrum antibiotic from the fluoroquinolone class, used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
500 mg once daily for 7-14 days, depending on the type and severity of infection. For certain infections, 750 mg once daily may be prescribed.
Elderly
No specific dose adjustment generally required, but monitor renal function due to age-related decline.
Renal_impairment
Dose adjustment required for creatinine clearance < 50 mL/min. Refer to specific dosing guidelines.
How to Take
Alinix 500 mg Tablet can be taken with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Alinofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours of administration.
Excretion
Primarily excreted unchanged via the kidneys (glomerular filtration and tubular secretion).
Half life
Approximately 6-8 hours.
Absorption
Rapidly and almost completely absorbed after oral administration. Bioavailability is approximately 99%.
Metabolism
Minimally metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Alinofloxacin or any other fluoroquinolone antibiotic.
- History of tendon disorders or rupture associated with fluoroquinolone use.
- Patients with epilepsy or other seizure disorders.
- Children and adolescents (under 18 years of age).
Drug Interactions
Warfarin
Alinofloxacin may enhance the anticoagulant effect of warfarin, requiring close monitoring of INR.
Corticosteroids
Concomitant use may increase the risk of tendon disorders, including tendon rupture.
Non-steroidal anti-inflammatory drugs (NSAIDs)
May increase the risk of CNS stimulation and convulsive seizures when used with fluoroquinolones.
Antacids (containing magnesium, aluminum, sucralfate)
May significantly reduce the absorption of Alinofloxacin. Take Alinofloxacin at least 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered to reduce absorption. Hemodialysis or peritoneal dialysis are not effective in removing Alinofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as Alinofloxacin is excreted into breast milk and may cause adverse effects in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Alinofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections across different patient populations.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with pre-existing renal impairment)
- Liver function tests (if signs of hepatotoxicity appear)
- Complete Blood Count (CBC)
- Electrocardiogram (ECG) in patients at risk for QT prolongation
Doctor Notes
- Emphasize to patients the importance of completing the full course of treatment.
- Advise patients to report any signs of tendonitis, neuropathy, or CNS disturbances immediately.
- Consider dose adjustment in patients with renal impairment.
- Counsel patients on potential drug-food interactions, especially with dairy products and antacids.
Patient Guidelines
- Complete the full course of Alinix as prescribed, even if symptoms improve, to prevent recurrence and antibiotic resistance.
- Stay well-hydrated by drinking plenty of fluids.
- Avoid excessive sun exposure and use sunscreen, as fluoroquinolones can increase photosensitivity.
- Report any pain, swelling, or inflammation in tendons (especially in the ankle, heel, or shoulder) immediately to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Alinix may cause dizziness, lightheadedness, or visual disturbances. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Avoid alcohol consumption during treatment with Alinix.
- Maintain a balanced diet to support overall health and recovery.
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