Allertin-ODT
Generic Name
Levocetirizine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| allertin odt 10 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Allertin-ODT 10 mg Tablet contains Levocetirizine, a third-generation antihistamine, used for the relief of symptoms associated with allergic conditions such as seasonal and perennial allergic rhinitis, and chronic idiopathic urticaria. The Orally Disintegrating Tablet (ODT) formulation dissolves rapidly in the mouth without water, providing quicker relief.
Uses & Indications
Dosage
Adults
The usual recommended dose is 5-10 mg orally once daily. Allertin-ODT 10 mg is usually prescribed as 10 mg once daily.
Elderly
No specific dose adjustment is needed unless there is underlying renal impairment. In such cases, dose should be adjusted based on renal function.
Renal_impairment
Dose adjustment is necessary for patients with impaired renal function based on creatinine clearance (CrCl): CrCl 30-49 mL/min: 5 mg once daily; CrCl 10-29 mL/min: 5 mg every other day. Not recommended for CrCl < 10 mL/min.
How to Take
Place the orally disintegrating tablet on the tongue and allow it to dissolve completely before swallowing. No water is needed. Can be taken with or without food, preferably in the evening.
Mechanism of Action
Levocetirizine is a potent, selective H1-receptor antagonist. It exerts its antihistaminic effect by selectively blocking histamine H1 receptors, thereby preventing the actions of histamine, such as vasodilation, increased capillary permeability, and itching, which are characteristic of allergic reactions.
Pharmacokinetics
Onset
Onset of action typically occurs within 15-30 minutes for Orally Disintegrating Tablets.
Excretion
Primarily excreted via the urine (approximately 85.4% of the dose) as unchanged drug (about 77%).
Half life
Plasma elimination half-life is approximately 7-10 hours.
Absorption
Rapidly absorbed following oral administration. Peak plasma concentrations are achieved approximately 0.9-1 hour after administration. Food may delay the rate but not the extent of absorption.
Metabolism
Levocetirizine is minimally metabolized in the liver (less than 14% of the dose).
Side Effects
Contraindications
- •Hypersensitivity to levocetirizine, cetirizine, or any component of the formulation
- •End-stage renal disease (CrCl < 10 mL/min) or patients undergoing hemodialysis
Drug Interactions
Alcohol and CNS Depressants
Concurrent use with alcohol or other CNS depressants (e.g., sedatives, hypnotics, opioids) may cause additive central nervous system depression, potentially impairing cognitive function and motor skills.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness in adults and agitation or restlessness followed by drowsiness in children. There is no specific antidote. Treatment should be symptomatic and supportive. Gastric lavage may be considered if recent ingestion. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm, but adequate studies in pregnant women are lacking. Use only if clearly needed. Levocetirizine is excreted in human breast milk; therefore, use is not recommended during lactation unless the potential benefits outweigh the potential risks to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Expired
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