Allyol
Generic Name
Allyzepam
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| allynol 5 mg tablet | ৳ 8.00 | ৳ 120.00 |
Description
Overview of the medicine
Allyol 5 mg Tablet is used for the short-term relief of anxiety symptoms, panic disorders, and insomnia. It belongs to a class of medicines known as anxiolytics.
Uses & Indications
Dosage
Adults
General anxiety: 0.5-1 mg two to three times daily. Max 4 mg/day. Insomnia: 1-2 mg at bedtime.
Elderly
Lower doses starting from 0.25 mg two times daily. Max 2 mg/day.
Renal_impairment
No specific dose adjustment for mild to moderate impairment, but caution advised. Consider lower doses for severe impairment.
How to Take
Take orally with water, with or without food. Do not crush or chew the tablet.
Mechanism of Action
Allyzepam enhances the effect of gamma-aminobutyric acid (GABA) in the brain, which is a neurotransmitter that inhibits nerve activity. This leads to a calming effect on the brain and central nervous system.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Approximately 10-15 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver via oxidative pathways.
Side Effects
Contraindications
- Hypersensitivity to Allyzepam or other benzodiazepines
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Severe hepatic impairment
- Myasthenia gravis
Drug Interactions
Opioids
Increased risk of sedation, respiratory depression, coma, and death.
Antifungals (e.g., Ketoconazole)
May inhibit metabolism, increasing Allyzepam levels.
Alcohol and other CNS depressants
Potentiation of sedative effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, confusion, impaired coordination, diminished reflexes, and coma. Treatment is mainly supportive, including airway management and intravenous fluids. Flumazenil may be considered in severe cases.
Pregnancy & Lactation
Should be avoided during pregnancy, especially during the first trimester, due to potential risk of congenital malformations. Excreted in breast milk, so not recommended during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Allyzepam or other benzodiazepines
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Severe hepatic impairment
- Myasthenia gravis
Drug Interactions
Opioids
Increased risk of sedation, respiratory depression, coma, and death.
Antifungals (e.g., Ketoconazole)
May inhibit metabolism, increasing Allyzepam levels.
Alcohol and other CNS depressants
Potentiation of sedative effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, confusion, impaired coordination, diminished reflexes, and coma. Treatment is mainly supportive, including airway management and intravenous fluids. Flumazenil may be considered in severe cases.
Pregnancy & Lactation
Should be avoided during pregnancy, especially during the first trimester, due to potential risk of congenital malformations. Excreted in breast milk, so not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Allyzepam has undergone several clinical trials demonstrating its efficacy and safety in the treatment of anxiety and insomnia. Post-marketing surveillance continues to monitor long-term effects.
Lab Monitoring
- Liver function tests (periodically, especially with long-term use)
- Kidney function tests (for severe impairment)
Doctor Notes
- Educate patients about the risk of dependence and withdrawal. Prescribe the lowest effective dose for the shortest duration necessary.
- Monitor patients for signs of respiratory depression, especially when co-administered with opioids.
- Assess for suicidal ideation, especially during initial therapy or dose adjustments.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor, as it can cause withdrawal symptoms.
- Avoid driving or operating heavy machinery until you know how this medicine affects you.
- Report any unusual mood changes or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine can cause drowsiness and impair coordination, affecting your ability to drive or operate machinery. Avoid these activities until you are certain you can perform them safely.
Lifestyle Advice
- Practice stress reduction techniques like meditation or yoga.
- Maintain a regular sleep schedule.
- Avoid caffeine and nicotine, especially in the evening.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.