Alphapress XR
Generic Name
Metoprolol Succinate Extended-Release
Manufacturer
AstraZeneca
Country
Sweden
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alphapress xr 5 mg tablet | ৳ 17.00 | ৳ 170.00 |
| alphapress xr 25 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Alphapress XR is a beta-blocker used to treat hypertension and angina.
Uses & Indications
Dosage
Adults
Hypertension: 25-100 mg once daily. Angina: 100-200 mg once daily. Heart Failure: Initial dose 12.5-25 mg once daily.
Elderly
Initiate at lower end of dosage range.
Renal_impairment
No dosage adjustment generally required. Monitor renal function.
How to Take
Swallow whole, do not crush or chew. Take with or without food.
Mechanism of Action
Selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate and blood pressure.
Pharmacokinetics
Onset
1-2 hours
Excretion
Renal
Half life
3-7 hours
Absorption
Well absorbed, but undergoes first-pass metabolism.
Metabolism
Hepatic
Side Effects
Contraindications
- Severe bradycardia
- Uncompensated heart failure
- Sick sinus syndrome
- 2nd or 3rd degree AV block
Drug Interactions
Digoxin
Increased risk of bradycardia.
Calcium Channel Blockers
Increased risk of bradycardia and hypotension.
CYP2D6 Inhibitors (e.g., fluoxetine, paroxetine, quinidine)
May increase metoprolol levels.
Storage
Store at room temperature (20-25°C). Protect from moisture.
Overdose
Bradycardia, hypotension, heart failure, bronchospasm, hypoglycemia. Treatment is symptomatic and supportive. Administer atropine for bradycardia; administer vasopressors for hypotension.
Pregnancy & Lactation
Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when metoprolol is administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved, DGDA Approved
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Multiple clinical trials have demonstrated the efficacy of metoprolol succinate extended-release in treating hypertension and heart failure.
Lab Monitoring
- Blood pressure
- Heart rate
- Renal function tests
- Liver function tests
Doctor Notes
- Start with a low dose and titrate up gradually.
- Monitor for signs and symptoms of heart failure.
Patient Guidelines
- Take medication as prescribed.
- Monitor blood pressure and heart rate regularly.
- Avoid abrupt cessation of therapy.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or fatigue, use caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet.
- Engage in regular physical activity.
- Limit alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.