Altrax
Generic Name
Hydroxyzine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| altrax 40 mg syrup | ৳ 15.00 | N/A |
Description
Overview of the medicine
Hydroxyzine is an antihistamine with sedative and anxiolytic properties. It is used to treat anxiety, tension, pruritus due to allergic conditions, and as a pre-operative sedative.
Uses & Indications
Dosage
Adults
Anxiety: 50-100 mg orally 3-4 times daily. Pruritus: 25 mg orally 3-4 times daily.
Elderly
Start with lower doses, e.g., 25 mg daily.
Renal_impairment
Dosage reduction may be necessary. Administer 50% of the usual dose.
How to Take
Oral administration. Can be taken with or without food. Measure syrup carefully with a dosing spoon or syringe.
Mechanism of Action
Hydroxyzine acts as an H1 receptor antagonist, blocking histamine receptors in the brain and periphery. It also has anticholinergic and mild dopamine blocking properties, contributing to its sedative and anxiolytic effects.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Mainly via kidneys, as cetirizine and other metabolites.
Half life
Approximately 20-25 hours (adults), 7 hours (children)
Absorption
Rapidly absorbed from the GI tract.
Metabolism
Primarily hepatic, metabolized to cetirizine (active metabolite) by alcohol dehydrogenase.
Side Effects
Contraindications
- Hypersensitivity to hydroxyzine, cetirizine, or any components
- Early pregnancy (first trimester)
- QT prolongation
- Breastfeeding
Drug Interactions
CNS Depressants
Increased sedation with alcohol, opioids, benzodiazepines.
Anticholinergics
Potentiated anticholinergic effects.
QT-prolonging drugs
Increased risk of QT prolongation and cardiac arrhythmias.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include excessive sedation, seizures, stupor, coma. Management involves supportive care, gastric lavage if recent, and monitoring vital signs. No specific antidote.
Pregnancy & Lactation
Contraindicated in early pregnancy and during breastfeeding. May cause fetal abnormalities and drowsiness in infants.
Side Effects
Contraindications
- Hypersensitivity to hydroxyzine, cetirizine, or any components
- Early pregnancy (first trimester)
- QT prolongation
- Breastfeeding
Drug Interactions
CNS Depressants
Increased sedation with alcohol, opioids, benzodiazepines.
Anticholinergics
Potentiated anticholinergic effects.
QT-prolonging drugs
Increased risk of QT prolongation and cardiac arrhythmias.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include excessive sedation, seizures, stupor, coma. Management involves supportive care, gastric lavage if recent, and monitoring vital signs. No specific antidote.
Pregnancy & Lactation
Contraindicated in early pregnancy and during breastfeeding. May cause fetal abnormalities and drowsiness in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical data available supporting its use for anxiety and pruritus.
Lab Monitoring
- ECG (for QT prolongation risk)
- Liver function tests (in prolonged use or hepatic impairment)
Doctor Notes
- Caution in elderly due to increased sensitivity and potential for anticholinergic effects.
- Monitor for QT prolongation, especially in patients with pre-existing cardiac conditions.
- Avoid concomitant use with other CNS depressants.
Patient Guidelines
- Do not drive or operate heavy machinery due to drowsiness.
- Avoid alcohol consumption.
- Inform your doctor if you have heart problems or epilepsy.
- Take exactly as prescribed.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
May cause drowsiness and impair ability to drive or operate machinery. Patients should be warned.
Lifestyle Advice
- Maintain a regular sleep schedule to help with anxiety.
- Practice relaxation techniques.
- Avoid caffeine and other stimulants.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.