Spasmonil, Alverine, Spasmin
Generic Name
alverin
Manufacturer
Various (e.g., Incepta, Square, Beximco in BD)
Country
Global, many manufacturers
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Description
Overview of the medicine
Alverin is a musculotropic antispasmodic agent used to relieve pain and spasms of the gastrointestinal tract and uterus. It is commonly used for Irritable Bowel Syndrome (IBS) and dysmenorrhea.
Uses & Indications
Dosage
Adults
60 mg to 120 mg, 1 to 3 times daily, preferably before meals. Max 360 mg/day.
Elderly
No specific dose adjustment is usually required, but caution is advised.
Renal_impairment
No specific dose adjustment required, but use with caution in severe impairment.
How to Take
Swallow capsules/tablets whole with water, preferably 30 minutes before meals.
Mechanism of Action
Alverin acts directly on the smooth muscles of the gastrointestinal tract and uterus, causing relaxation and reducing spasms. Its exact mechanism is not fully understood but is thought to involve inhibition of calcium channels in smooth muscle cells.
Pharmacokinetics
Onset
Onset of action is relatively quick, usually within 30-60 minutes.
Excretion
Mainly excreted via urine and feces.
Half life
Short, due to rapid metabolism.
Absorption
Readily absorbed from the gastrointestinal tract, but undergoes extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver to active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to alverin or any of its components
- Paralytic ileus
- Intestinal obstruction
- Children under 12 years of age
Drug Interactions
No significant interactions reported
Alverin is generally not known to have significant drug-drug interactions. Always inform your doctor about all medications you are taking.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include hypotension, dizziness, and possibly gastrointestinal disturbances. Management is symptomatic and supportive, including gastric lavage if recent ingestion.
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to insufficient data on safety. Consult your doctor before use if you are pregnant, planning to become pregnant, or breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved in many countries
Patent Status
Off-patent
Clinical Trials
Alverin has been evaluated in various clinical trials for its efficacy in relieving symptoms of Irritable Bowel Syndrome (IBS) and other functional bowel disorders.
Lab Monitoring
- Routine lab monitoring is not typically required unless liver function abnormalities are suspected or during long-term use.
Doctor Notes
- Ensure diagnosis of IBS is accurate and exclude other serious conditions before prescribing.
- Advise patients on lifestyle modifications alongside medication.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor if symptoms persist or worsen.
- Do not crush or chew the capsules/tablets.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Alverin may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating machinery.
Lifestyle Advice
- For IBS, consider dietary adjustments (e.g., low FODMAP diet) and stress management techniques.
- Maintain a healthy lifestyle with regular exercise and adequate fluid intake.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.