Alverine
Generic Name
Alverine Citrate 60 mg Tablet
Manufacturer
Various (e.g., Sanofi, Beximco Pharma, Square Pharmaceuticals)
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alverin 60 mg tablet | ৳ 5.02 | ৳ 50.20 |
Description
Overview of the medicine
Alverine is an antispasmodic drug primarily used to relieve abdominal pain caused by spasms of the gastrointestinal smooth muscle, particularly in conditions like Irritable Bowel Syndrome (IBS) and diverticular disease.
Uses & Indications
Dosage
Adults
60 mg to 120 mg, 1 to 3 times daily, before meals.
Elderly
No specific dosage adjustment required, but caution is advised. Start with lower dose if necessary.
Renal_impairment
No specific dosage adjustment guidelines available. Use with caution.
How to Take
Oral administration. Tablets should be swallowed whole with water, preferably before meals.
Mechanism of Action
Alverine is a direct acting musculotropic antispasmodic. It acts directly on the smooth muscle of the gastrointestinal tract, causing relaxation and reducing spasms, thereby alleviating pain. It does not possess anticholinergic properties.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Primarily excreted via the kidneys (urine) as metabolites.
Half life
Approximately 0.5 to 1 hour (active metabolite has longer half-life)
Absorption
Readily absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1-1.5 hours.
Metabolism
Extensively metabolized in the liver to active and inactive metabolites, primarily via hydrolysis.
Side Effects
Contraindications
- Hypersensitivity to Alverine or any excipients
- Paralytic ileus
- Intestinal obstruction
- Children under 12 years of age (generally not recommended)
Drug Interactions
No significant clinically relevant drug interactions have been reported
No significant clinically relevant drug interactions have been reported with Alverine at therapeutic doses.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hypotension, lightheadedness, and mydriasis. Treatment is symptomatic and supportive, including gastric lavage if ingested recently.
Pregnancy & Lactation
Use during pregnancy is not recommended unless clearly necessary and the potential benefits outweigh the risks. Limited data available on excretion in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Alverine or any excipients
- Paralytic ileus
- Intestinal obstruction
- Children under 12 years of age (generally not recommended)
Drug Interactions
No significant clinically relevant drug interactions have been reported
No significant clinically relevant drug interactions have been reported with Alverine at therapeutic doses.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hypotension, lightheadedness, and mydriasis. Treatment is symptomatic and supportive, including gastric lavage if ingested recently.
Pregnancy & Lactation
Use during pregnancy is not recommended unless clearly necessary and the potential benefits outweigh the risks. Limited data available on excretion in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by various national regulatory bodies (e.g., MHRA, DGDA)
Patent Status
Generic available
Clinical Trials
Alverine has been studied in numerous clinical trials for its efficacy in treating IBS and other spasmodic gastrointestinal conditions, demonstrating symptomatic relief.
Lab Monitoring
- Routine monitoring not typically required. Liver function tests may be considered in patients with pre-existing hepatic impairment or during long-term therapy if clinically indicated.
Doctor Notes
- Alverine is a good first-line agent for abdominal spasms where anticholinergic effects are undesired.
- Advise patients on lifestyle modifications along with medication for optimal IBS management.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a forgotten dose.
Driving Precautions
Alverine is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet and regular exercise.
- Manage stress, as it can worsen IBS symptoms.
- Avoid trigger foods if you have IBS.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.