Ambrocod
Generic Name
Ambroxol Hydrochloride + Codeine Phosphate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ambrocod 15 mg syrup | ৳ 40.00 | N/A |
Description
Overview of the medicine
Ambrocod 15 mg Syrup is a combination medication used to relieve cough associated with various respiratory conditions. It acts as an expectorant, mucolytic, and antitussive.
Uses & Indications
Dosage
Adults
5-10 mL (1-2 teaspoonfuls) two to three times daily, or as directed by physician.
Elderly
Same as adults, but caution should be exercised, and dose reduction may be necessary in case of renal or hepatic impairment.
Renal_impairment
Use with caution. Dosage adjustment may be required based on the degree of impairment.
How to Take
Oral administration. Can be taken with or without food. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Ambroxol increases mucociliary clearance by thinning and loosening mucus, facilitating its removal from the respiratory tract. Codeine acts centrally on the cough center in the medulla to suppress the cough reflex.
Pharmacokinetics
Onset
Ambroxol: Onset of action within 30 minutes. Codeine: Antitussive effect typically within 30-60 minutes.
Excretion
Ambroxol is primarily excreted renally. Codeine and its metabolites are mainly excreted in the urine.
Half life
Ambroxol: Terminal plasma half-life is approximately 10 hours. Codeine: Plasma half-life is approximately 2.9 hours.
Absorption
Ambroxol is rapidly and almost completely absorbed after oral administration, with high bioavailability. Codeine is rapidly absorbed from the gastrointestinal tract.
Metabolism
Ambroxol undergoes extensive first-pass metabolism in the liver. Codeine is metabolized in the liver, primarily via O-demethylation to morphine by CYP2D6.
Side Effects
Contraindications
- •Hypersensitivity to Ambroxol, Codeine, or any components of the syrup
- •Severe respiratory depression or acute respiratory conditions such as status asthmaticus
- •Children under 12 years of age due to the risk of codeine toxicity
- •Recent head injury or increased intracranial pressure
- •Liver impairment
Drug Interactions
CNS depressants
Concomitant use with other CNS depressants (e.g., alcohol, sedatives, hypnotics, opioids) can increase the risk of sedation, respiratory depression, and coma.
Anticholinergics
Concurrent use may increase the risk of severe constipation and paralytic ileus due to additive effects on gastrointestinal motility.
CYP2D6 inhibitors
Drugs that inhibit CYP2D6 (e.g., quinidine, fluoxetine, paroxetine) may reduce the conversion of codeine to morphine, potentially decreasing its analgesic and antitussive efficacy.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, respiratory depression (slow, shallow breathing), pinpoint pupils, confusion, cold and clammy skin, and loss of consciousness. Management involves supportive care, maintaining airway and ventilation, and administration of naloxone (an opioid antagonist) for codeine toxicity.
Pregnancy & Lactation
Pregnancy: Not recommended during pregnancy, especially in the third trimester, due to the risk of neonatal opioid withdrawal syndrome. Category C. Lactation: Not recommended for breastfeeding mothers, as codeine is metabolized to morphine and can be excreted into breast milk, potentially causing serious adverse reactions, including respiratory depression, in nursing infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture, specified on the packaging.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Expired
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Global Brand Names
International brand names for this medicine
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