Ambuterol
Generic Name
Ambuterol 5 mg Oral Solution
Manufacturer
Example Pharma Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ambuterol 5 mg oral solution | ৳ 20.00 | N/A |
Description
Overview of the medicine
Ambuterol 5 mg Oral Solution is a bronchodilator used to relieve symptoms of asthma and chronic obstructive pulmonary disease (COPD), such as wheezing, shortness of breath, and chest tightness. It works by relaxing the muscles in the airways.
Uses & Indications
Dosage
Adults
Typically 5 ml (5 mg) three or four times daily. May be increased to 10 ml (10 mg) if necessary.
Elderly
Initial dosage may be lower; adjust according to clinical response and tolerability.
Renal_impairment
No specific dosage adjustment recommended for mild to moderate renal impairment; use with caution in severe impairment.
How to Take
For oral use. Measure the dose accurately using the provided measuring spoon or cup. Can be taken with or without food.
Mechanism of Action
Ambuterol selectively stimulates beta-2 adrenergic receptors in the bronchial smooth muscle, leading to muscle relaxation and bronchodilation. It also inhibits the release of mediators from mast cells in the airways.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Mainly excreted in the urine as metabolites and unchanged drug.
Half life
Approximately 3.7-5 hours
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 2-3 hours after oral administration.
Metabolism
Primarily metabolized in the liver via sulfation to an inactive conjugate.
Side Effects
Contraindications
- Hypersensitivity to ambuterol or any excipients
- Cardiomyopathy with outflow tract obstruction
- Previous history of paradoxical bronchospasm with a beta-agonist
Drug Interactions
Diuretics (e.g., furosemide)
May potentiate hypokalemia.
Beta-blockers (e.g., propranolol)
Can antagonize the effects of ambuterol and cause severe bronchospasm.
MAO inhibitors and Tricyclic antidepressants
Increased risk of cardiovascular effects.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms include tachycardia, tremors, palpitations, headache, and hypokalemia. Management involves symptomatic and supportive therapy, with consideration of cautious use of a cardioselective beta-blocker if severe cardiovascular effects occur.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether ambuterol is excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Clinical trials demonstrated significant improvement in FEV1 and reduction in asthma symptoms compared to placebo. Long-term safety and efficacy studies are ongoing.
Lab Monitoring
- Monitor serum potassium levels, especially in patients receiving concomitant diuretics or corticosteroids.
- Monitor blood glucose in diabetic patients.
Doctor Notes
- Advise patients on proper administration technique.
- Emphasize not to use this medication for acute severe asthma exacerbations without medical supervision.
- Monitor for signs of cardiovascular adverse effects, especially in patients with pre-existing cardiac conditions.
Patient Guidelines
- Do not exceed the prescribed dose.
- Seek medical attention if symptoms worsen or if the usual dose becomes less effective.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Ambuterol may cause tremors or dizziness in some patients, which could affect the ability to drive or operate machinery. Exercise caution until you know how the medicine affects you.
Lifestyle Advice
- Avoid smoking and exposure to respiratory irritants.
- Maintain good hydration.
- Regular exercise as tolerated, avoiding triggers.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.