Amezol
Generic Name
Metronidazole
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amezol 200 mg suspension | ৳ 28.50 | N/A |
Description
Overview of the medicine
Amezol 200 mg suspension contains Metronidazole, an antibiotic and antiprotozoal medication used to treat a wide variety of infections, including parasitic infections and certain bacterial infections.
Uses & Indications
Dosage
Adults
Adult dosage for amoebiasis: 400-800 mg three times daily for 5-10 days (typically tablets). For suspension, dosage based on body weight for specific indications.
Elderly
Dose adjustment may be necessary in elderly patients due to reduced hepatic function.
Renal_impairment
No dose adjustment is generally required in renal impairment, but caution is advised in severe cases.
How to Take
Take orally, with or after food, to minimize gastrointestinal upset. Shake the suspension well before use. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Metronidazole acts as a prodrug. After entering anaerobic bacteria or protozoa, it is reduced by electron transport proteins to reactive cytotoxic compounds. These compounds bind to and damage DNA, inhibiting nucleic acid synthesis and leading to cell death.
Pharmacokinetics
Onset
Usually within 1-2 hours.
Excretion
Mainly excreted in the urine (60-80%) as unchanged drug and metabolites; a small amount (6-15%) is excreted in feces.
Half life
Approximately 6-8 hours.
Absorption
Rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver by oxidation with side-chain cleavage and glucuronide conjugation.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives
- First trimester of pregnancy (relative contraindication)
- Disulfiram use within the last 14 days
Drug Interactions
Alcohol
Disulfiram-like reaction (abdominal cramps, nausea, vomiting, headaches, flushing).
Lithium
Increased plasma lithium levels, leading to toxicity.
Warfarin
Increased anticoagulant effect, leading to increased risk of bleeding.
Disulfiram
Psychotic reactions.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, ataxia, and mild disorientation. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Generally avoided in the first trimester of pregnancy. Use in later trimesters or during lactation only if clearly needed and benefits outweigh risks. Metronidazole is excreted into breast milk.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives
- First trimester of pregnancy (relative contraindication)
- Disulfiram use within the last 14 days
Drug Interactions
Alcohol
Disulfiram-like reaction (abdominal cramps, nausea, vomiting, headaches, flushing).
Lithium
Increased plasma lithium levels, leading to toxicity.
Warfarin
Increased anticoagulant effect, leading to increased risk of bleeding.
Disulfiram
Psychotic reactions.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, ataxia, and mild disorientation. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Generally avoided in the first trimester of pregnancy. Use in later trimesters or during lactation only if clearly needed and benefits outweigh risks. Metronidazole is excreted into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored properly.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of metronidazole for various anaerobic and protozoal infections over decades.
Lab Monitoring
- Liver function tests (in prolonged therapy)
- Complete blood count (in prolonged therapy)
Doctor Notes
- Counsel patients on strict alcohol avoidance.
- Advise patients about potential metallic taste and darkened urine.
- Monitor for neurological symptoms if therapy is prolonged.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Avoid alcohol during treatment and for at least 3 days afterward.
- Report any unusual or severe side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or disorientation. Avoid driving or operating machinery if you experience these symptoms.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection, especially for parasitic infections.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea or vomiting.
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