Amicoxib
Generic Name
Amicoxib
Manufacturer
Generic Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amicoxib 90 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Amicoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, a type of non-steroidal anti-inflammatory drug (NSAID), used to relieve pain and inflammation associated with various conditions.
Uses & Indications
Dosage
Adults
Osteoarthritis: 60 mg once daily. Rheumatoid arthritis, Ankylosing Spondylitis: 90 mg once daily. Acute Gout: 120 mg once daily for a maximum of 8 days. Acute Pain/Dysmenorrhea: 90 mg once daily, maximum for 5 days.
Elderly
No specific dose adjustment is required based on age, but caution is advised due to potential age-related decline in renal function.
Renal_impairment
Mild to moderate renal impairment (CrCl 30-80 mL/min): No dose adjustment. Severe renal impairment (CrCl <30 mL/min): Not recommended.
How to Take
Take Amicoxib tablets orally, with or without food. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
Mechanism of Action
Amicoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins, mediators of pain, inflammation, and fever. By inhibiting COX-2, it reduces prostaglandin production, leading to anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Analgesic effects typically begin within 1-2 hours after oral administration.
Excretion
Excreted predominantly in the urine (approximately 70%) and feces (approximately 30%) as metabolites.
Half life
The elimination half-life is approximately 10-15 hours.
Absorption
Amicoxib is well absorbed orally, achieving peak plasma concentrations within 1-2 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 (CYP) enzymes, mainly CYP3A4, to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Amicoxib or any excipients
- Active peptic ulceration or gastrointestinal bleeding
- Severe heart failure (NYHA Class II-IV)
- Ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- Severe hepatic dysfunction
- Severe renal dysfunction (creatinine clearance <30 mL/min)
- History of asthma, acute rhinitis, nasal polyps, angioneurotic edema, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Third trimester of pregnancy
Drug Interactions
Lithium
Amicoxib may increase plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma concentration and toxicity of methotrexate.
Oral contraceptives
May increase plasma concentrations of oral contraceptives.
Warfarin and other anticoagulants
Increased risk of bleeding due to enhanced anticoagulant effect.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects.
ACE inhibitors and Angiotensin II Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptoms may include gastrointestinal disturbances (e.g., nausea, vomiting, abdominal pain), drowsiness, and headache. More severe cases may lead to GI bleeding, acute renal failure, or anaphylactoid reactions. Management is primarily supportive. Gastric lavage and activated charcoal may be considered if ingestion is recent. Monitor vital signs and renal function.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid Amicoxib during the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus. Use with caution during lactation; it is unknown if Amicoxib is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Amicoxib or any excipients
- Active peptic ulceration or gastrointestinal bleeding
- Severe heart failure (NYHA Class II-IV)
- Ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- Severe hepatic dysfunction
- Severe renal dysfunction (creatinine clearance <30 mL/min)
- History of asthma, acute rhinitis, nasal polyps, angioneurotic edema, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Third trimester of pregnancy
Drug Interactions
Lithium
Amicoxib may increase plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma concentration and toxicity of methotrexate.
Oral contraceptives
May increase plasma concentrations of oral contraceptives.
Warfarin and other anticoagulants
Increased risk of bleeding due to enhanced anticoagulant effect.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects.
ACE inhibitors and Angiotensin II Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptoms may include gastrointestinal disturbances (e.g., nausea, vomiting, abdominal pain), drowsiness, and headache. More severe cases may lead to GI bleeding, acute renal failure, or anaphylactoid reactions. Management is primarily supportive. Gastric lavage and activated charcoal may be considered if ingestion is recent. Monitor vital signs and renal function.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid Amicoxib during the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus. Use with caution during lactation; it is unknown if Amicoxib is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, hospitals
Approval Status
DGDA Approved
Patent Status
Off-patent
Clinical Trials
Amicoxib, as a COX-2 inhibitor, has undergone various clinical trials to establish its efficacy and safety in conditions such as osteoarthritis, rheumatoid arthritis, and acute pain. Post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Renal function (creatinine, BUN) should be monitored periodically, especially in elderly or renally impaired patients.
- Liver function tests (ALT, AST) should be monitored in patients with pre-existing hepatic impairment or during long-term therapy.
- Blood pressure should be monitored regularly.
- Complete blood count (CBC) may be monitored during long-term therapy for signs of anemia or other hematologic abnormalities.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Assess cardiovascular risk factors (e.g., hypertension, hyperlipidemia, diabetes) before initiating and periodically during Amicoxib therapy.
- Consider co-administration of gastroprotective agents (e.g., PPIs) for patients at high risk of gastrointestinal complications, especially those with a history of ulcers or bleeding.
- Monitor renal function, liver function, and blood pressure periodically, especially in elderly or vulnerable patients.
Patient Guidelines
- Take Amicoxib exactly as prescribed by your doctor and do not exceed the recommended dose.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools, severe stomach pain) or cardiovascular events (e.g., chest pain, shortness of breath, sudden weakness) to your doctor immediately.
- Do not take other NSAIDs (including aspirin) concurrently without consulting your doctor.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Amicoxib may cause dizziness, drowsiness, or visual disturbances in some patients. Patients should be advised to exercise caution when driving or operating machinery until they know how Amicoxib affects them.
Lifestyle Advice
- Limit alcohol intake while taking Amicoxib, as it may increase the risk of stomach irritation and bleeding.
- Maintain a healthy diet and lifestyle, including regular exercise, to support overall well-being and manage underlying conditions.
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