Amikin
Generic Name
Amikacin Sulfate
Manufacturer
Bristol-Myers Squibb
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amikin 100 mg injection | ৳ 16.00 | N/A |
| amikin 500 mg injection | ৳ 48.00 | N/A |
Description
Overview of the medicine
Amikin (Amikacin Sulfate) is an aminoglycoside antibiotic used for short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.
Uses & Indications
Dosage
Adults
15 mg/kg/day divided q8-12h
Elderly
Adjust dose based on renal function. Start with lower end of adult dose range.
Renal_impairment
Adjust dose and frequency based on creatinine clearance.
How to Take
Administered intravenously or intramuscularly. Monitor renal function and hearing during treatment.
Mechanism of Action
Amikacin works by binding to the 30S ribosomal subunit of bacteria, inhibiting protein synthesis and leading to bacterial cell death.
Pharmacokinetics
Onset
Within hours of administration
Excretion
Primarily excreted unchanged in the urine via glomerular filtration.
Half life
2-3 hours in patients with normal renal function
Absorption
Rapidly absorbed intramuscularly. Peak serum concentrations are usually achieved within 30-60 minutes.
Metabolism
Not significantly metabolized
Side Effects
Contraindications
- Hypersensitivity to aminoglycosides
- Pre-existing hearing impairment
Drug Interactions
Neuromuscular blocking agents
Increased risk of neuromuscular blockade
Loop diuretics (e.g., Furosemide)
Increased risk of ototoxicity
Storage
Store at room temperature (20-25°C). Protect from light.
Overdose
Hemodialysis may be effective in removing amikacin from the blood. Monitor renal function and electrolytes.
Pregnancy & Lactation
Category D: Risk to fetus. Use only if benefit outweighs risk. Caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to aminoglycosides
- Pre-existing hearing impairment
Drug Interactions
Neuromuscular blocking agents
Increased risk of neuromuscular blockade
Loop diuretics (e.g., Furosemide)
Increased risk of ototoxicity
Storage
Store at room temperature (20-25°C). Protect from light.
Overdose
Hemodialysis may be effective in removing amikacin from the blood. Monitor renal function and electrolytes.
Pregnancy & Lactation
Category D: Risk to fetus. Use only if benefit outweighs risk. Caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Hospitals and Pharmacies
Approval Status
FDA Approved/DGDA Approved
Patent Status
Off-Patent
WHO Essential Medicine
YesClinical Trials
Multiple clinical trials have demonstrated the efficacy of amikacin in treating Gram-negative infections.
Lab Monitoring
- Serum creatinine
- Hearing tests (audiometry)
Doctor Notes
- Monitor renal and auditory function closely during amikacin therapy.
- Adjust dosage based on patient's renal function.
Patient Guidelines
- Report any changes in hearing or kidney function to your doctor
- Stay well-hydrated
- Complete the full course of treatment
Missed Dose Advice
If a dose is missed, administer it as soon as possible. Do not double the dose.
Driving Precautions
Use caution when driving if experiencing dizziness or vertigo.
Lifestyle Advice
- Avoid other ototoxic medications if possible
- Maintain a healthy diet
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