Amisure
Generic Name
Misoprostol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amisure 5 mg injection | ৳ 60.00 | N/A |
Description
Overview of the medicine
Amisure is a synthetic prostaglandin E1 analog used to prevent gastric ulcers caused by NSAIDs, induce labor, and as an abortifacient.
Uses & Indications
Dosage
Adults
200 mcg four times daily with food for prevention of NSAID-induced ulcers. For medical management of miscarriage or induction of labor, dosage varies greatly and should be determined by a healthcare professional.
Elderly
Same as adults, with caution in patients with renal impairment.
Renal_impairment
Dosage adjustment may be necessary in patients with renal impairment.
How to Take
Tablets should be taken with food to minimize gastrointestinal side effects. Follow your doctor's instructions carefully.
Mechanism of Action
Misoprostol binds to prostaglandin E1 receptors on gastric parietal cells, inhibiting gastric acid secretion and increasing bicarbonate and mucus production, thus protecting the gastric mucosa. It also causes uterine contractions.
Pharmacokinetics
Onset
30 minutes
Excretion
Excreted primarily in the urine.
Half life
20-40 minutes
Absorption
Rapidly absorbed after oral administration.
Metabolism
Metabolized in the liver.
Side Effects
Contraindications
- Pregnancy (unless for medical termination)
- Hypersensitivity to misoprostol or other prostaglandins
Drug Interactions
Oxytocin
Increased risk of uterine rupture when used concurrently for induction of labor.
Antacids containing magnesium
May increase the risk of diarrhea.
Storage
Store below 30°C in a dry place, away from light.
Overdose
Symptoms of overdose may include sedation, tremor, convulsions, dyspnea, abdominal pain, diarrhea, fever, palpitations, hypotension, or bradycardia. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Contraindicated in pregnancy unless for medical termination. Caution should be exercised when administering misoprostol to nursing women.
Side Effects
Contraindications
- Pregnancy (unless for medical termination)
- Hypersensitivity to misoprostol or other prostaglandins
Drug Interactions
Oxytocin
Increased risk of uterine rupture when used concurrently for induction of labor.
Antacids containing magnesium
May increase the risk of diarrhea.
Storage
Store below 30°C in a dry place, away from light.
Overdose
Symptoms of overdose may include sedation, tremor, convulsions, dyspnea, abdominal pain, diarrhea, fever, palpitations, hypotension, or bradycardia. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Contraindicated in pregnancy unless for medical termination. Caution should be exercised when administering misoprostol to nursing women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies and hospitals
Approval Status
FDA Approved/DGDA Approved
Patent Status
Off-Patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of misoprostol for its various indications.
Lab Monitoring
- Complete Blood Count (CBC)
- Renal function tests
Doctor Notes
- Monitor patients for signs of uterine rupture, especially during induction of labor.
- Use with caution in patients with pre-existing cardiovascular disease.
Patient Guidelines
- Take with food.
- Avoid alcohol.
- Report any unusual bleeding or severe abdominal pain to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Use caution when driving or operating machinery.
Lifestyle Advice
- Stay hydrated.
- Eat a balanced diet.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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